دورية أكاديمية
Sprouting and connectivity of embryonic leech heart excitor (HE) motor neurons in the absence of their peripheral target.
| العنوان: | Sprouting and connectivity of embryonic leech heart excitor (HE) motor neurons in the absence of their peripheral target. |
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| المؤلفون: | Jellies J; Department of Biological Sciences, Western Michigan University, Kalamazoo 49008, USA., Kopp DM |
| المصدر: | Invertebrate neuroscience : IN [Invert Neurosci] 1995; Vol. 1 (2), pp. 145-57. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9602489 Publication Model: Print Cited Medium: Print ISSN: 1354-2516 (Print) Linking ISSN: 13542516 NLM ISO Abbreviation: Invert Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999-2020 : Heidelberg : Springer Verlag Original Publication: [Sheffield, England] : Sheffield Academic Press, [1995- |
| مواضيع طبية MeSH: | Embryo, Nonmammalian/*physiology , Heart Conduction System/*embryology , Leeches/*embryology , Motor Neurons/*physiology, Animals ; Denervation ; Embryo, Nonmammalian/cytology ; Heart Conduction System/cytology ; Motor Neurons/cytology ; Neural Pathways/physiology ; Synaptic Transmission/physiology |
| مستخلص: | The rhythmic pumping of the hearts in the medicinal leech, Hirudo medicinalis, is neurogenic and mediated by a defined circuit involving identified interneurons in a central pattern generator (CPG) and segmentally iterated motor neurons that drive the heart muscle. During early embryogenesis, presumptive heart excitor (HE) motor neurons extend many axon branches into the body wall; they later innervate the heart while retracting the supernumerary peripheral axons, and only much later in development receive synaptic input from the central pattern generator (Jellies, Kopp and Bledsoe (1992) J. Exp. Biol., 170, 71-92.). In this study, HE motor neurons were deprived of an early interaction with the heart by surgical ablation of a circumscribed portion of body wall including the heart primordium. Anatomical and electrophysiological data were obtained using intracellular techniques to examine the hypothesis that peripheral interactions with the developing heart provide instructive cues for the final differentiation of these neurons. Target-deprived HE motor neurons continued to extend multiple axons in ventral, lateral and dorsal body wall throughout late embryonic and into postembryonic stages and they extended anomalous axons within the CNS. This resembles the early embryonic growth of HE motor neurons before heart tube differentiation. Furthermore, HE motor neurons deprived of heart contact exhibited tonic activity similar to the situation during early development before they are contacted by the CPG interneurons. In contrast, sham-operated and contralateral HE motor neurons oscillated normally. These results suggest that heart tube contact is specifically required for at least some aspects of HE development and provide a framework in which to identify cell-cell interactions that are involved in matching neurons and targets to generate behaviorally relevant neural circuits. |
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| تواريخ الأحداث: | Date Created: 19950101 Date Completed: 19971219 Latest Revision: 20210107 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1007/BF02331912 |
| PMID: | 9372139 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1354-2516 |
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| DOI: | 10.1007/BF02331912 |