دورية أكاديمية
أعرض في EDS

Control of B cell development by Ras-mediated activation of Raf.

التفاصيل البيبلوغرافية
العنوان: Control of B cell development by Ras-mediated activation of Raf.
المؤلفون: Iritani BM; Department of Immunology, University of Washington, Seattle, WA 98195, USA., Forbush KA, Farrar MA, Perlmutter RM
المصدر: The EMBO journal [EMBO J] 1997 Dec 01; Vol. 16 (23), pp. 7019-31.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print Cited Medium: Print ISSN: 0261-4189 (Print) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
أسماء مطبوعة: Publication: 2024- : [London] : Nature Publishing Group
Original Publication: Eynsham, Oxford, England : Published for the European Molecular Biology Organization by IRL Press, [c1982-
مواضيع طبية MeSH: Hematopoiesis*, B-Lymphocytes/*physiology , Hematopoietic Stem Cells/*physiology , Proto-Oncogene Proteins c-raf/*metabolism , Proto-Oncogene Proteins p21(ras)/*metabolism, Animals ; B-Lymphocyte Subsets ; Bone Marrow Cells/cytology ; Cell Differentiation ; Cell Lineage ; Gene Expression Regulation ; Lymphocyte Depletion ; Mice ; Mice, Transgenic ; Models, Biological ; Proto-Oncogene Proteins p21(ras)/genetics ; Signal Transduction ; Spleen/cytology ; T-Lymphocytes/physiology
مستخلص: Cell fate commitment in a variety of lineages requires signals conveyed via p21ras. To examine the role of p21ras in the development of B lymphocytes, we generated transgenic mice expressing a dominant-negative form of Ras in B lymphocyte progenitors, using a novel transcriptional element consisting of the Emu enhancer and the lck proximal promoter. Expression of dominant-negative Ras arrests B cell development at a very early stage, prior to formation of the pre-B cell receptor. Furthermore, an activated form of Raf expressed in the same experimental system could both drive the maturation of normal pro-B cells and rescue development of progenitors expressing dominant-negative Ras. Hence p21ras normally regulates early development of B lymphocytes by a mechanism that involves activation of the serine/threonine kinase Raf.
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معلومات مُعتمدة: K08 AI001445-04 United States AI NIAID NIH HHS; K08 AI001445-05 United States AI NIAID NIH HHS; K08 AI001445-06 United States AI NIAID NIH HHS; T32 RR07019 United States RR NCRR NIH HHS
المشرفين على المادة: EC 2.7.11.1 (Proto-Oncogene Proteins c-raf)
EC 3.6.5.2 (Proto-Oncogene Proteins p21(ras))
تواريخ الأحداث: Date Created: 19980131 Date Completed: 19980129 Latest Revision: 20190508
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC1170305
DOI: 10.1093/emboj/16.23.7019
PMID: 9384581
قاعدة البيانات: MEDLINE
الوصف
تدمد:0261-4189
DOI:10.1093/emboj/16.23.7019