دورية أكاديمية
Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide.
| العنوان: | Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide. |
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| المؤلفون: | Selnick HG; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA., Liverton NJ, Baldwin JJ, Butcher JW, Claremon DA, Elliott JM, Freidinger RM, King SA, Libby BE, McIntyre CJ, Pribush DA, Remy DC, Smith GR, Tebben AJ, Jurkiewicz NK, Lynch JJ, Salata JJ, Sanguinetti MC, Siegl PK, Slaughter DE, Vyas K |
| المصدر: | Journal of medicinal chemistry [J Med Chem] 1997 Nov 21; Vol. 40 (24), pp. 3865-8. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington Dc : American Chemical Society Original Publication: [Easton, Pa.] : American Chemical Society, [c1963- |
| مواضيع طبية MeSH: | Potassium Channel Blockers*, Acetamides/*chemical synthesis , Acetamides/*pharmacology , Anti-Arrhythmia Agents/*chemical synthesis , Anti-Arrhythmia Agents/*pharmacology , Benzodiazepinones/*chemical synthesis , Benzodiazepinones/*pharmacology , Heart/*drug effects, Administration, Oral ; Animals ; Cells, Cultured ; Dogs ; Electrocardiography, Ambulatory/drug effects ; Guinea Pigs ; Heart/physiology ; Humans ; Myocardium/cytology ; Potassium Channels/physiology ; Xenopus |
| المشرفين على المادة: | 0 (Acetamides) 0 (Anti-Arrhythmia Agents) 0 (Benzodiazepinones) 0 (L 768673) 0 (Potassium Channel Blockers) 0 (Potassium Channels) |
| تواريخ الأحداث: | Date Created: 19971216 Date Completed: 19980112 Latest Revision: 20220408 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1021/jm970517u |
| PMID: | 9397166 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 0022-2623 |
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| DOI: | 10.1021/jm970517u |