دورية أكاديمية
Suppression of neuronal apoptosis by S-nitrosylation of caspases.
| العنوان: | Suppression of neuronal apoptosis by S-nitrosylation of caspases. |
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| المؤلفون: | Tenneti L; Cerebrovascular and NeuroScience Research Institute, Brigham and Women's Hospital, Boston, MA 02115, USA., D'Emilia DM, Lipton SA |
| المصدر: | Neuroscience letters [Neurosci Lett] 1997 Nov 07; Vol. 236 (3), pp. 139-42. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print Cited Medium: Print ISSN: 0304-3940 (Print) Linking ISSN: 03043940 NLM ISO Abbreviation: Neurosci Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Scientific Publishers Ireland Original Publication: Amsterdam, Elsevier/North-Holland. |
| مواضيع طبية MeSH: | Apoptosis/*physiology , Cysteine Endopeptidases/*metabolism , Neurons/*cytology , Neurons/*enzymology , Nitric Oxide/*metabolism, Calcimycin/analogs & derivatives ; Calcimycin/pharmacology ; Cell Line ; Cerebral Cortex/cytology ; Humans ; Ionophores/pharmacology ; Kidney/cytology ; Lac Operon ; Neurons/drug effects ; Nitric Oxide/pharmacology ; Nitric Oxide Synthase/metabolism ; Nitroso Compounds/metabolism ; Transfection |
| مستخلص: | S-Nitrosylation (reaction of nitric oxide (NO) species with a critical cysteine sulfhydryl) can regulate the physiological activity of proteins, including enzymes, ion channels, G-proteins, and transcription factors. Caspases are a family of interleukin-1beta-converting enzyme-like proteases involved in the signaling pathway to apoptotic cell death, and each member of this enzyme family contains a critical cysteine residue in its active site. Here we show that S-nitrosylation of caspases in human embryonic kidney (HEK)-293 cells and primary cerebrocortical neurons decreases enzyme activity and is associated with protection from apoptosis. |
| معلومات مُعتمدة: | P01 HD29587 United States HD NICHD NIH HHS |
| المشرفين على المادة: | 0 (Ionophores) 0 (Nitroso Compounds) 31C4KY9ESH (Nitric Oxide) 37H9VM9WZL (Calcimycin) 76455-48-6 (4-bromo-A-23187) EC 1.14.13.39 (Nitric Oxide Synthase) EC 3.4.22.- (Cysteine Endopeptidases) |
| تواريخ الأحداث: | Date Created: 19971224 Date Completed: 19980112 Latest Revision: 20190701 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/s0304-3940(97)00780-5 |
| PMID: | 9406756 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0304-3940 |
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| DOI: | 10.1016/s0304-3940(97)00780-5 |