دورية أكاديمية
Management of multiple drug-resistant malaria in Viet Nam.
| العنوان: | Management of multiple drug-resistant malaria in Viet Nam. |
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| المؤلفون: | Hien TT; Malaria Research Unit, Centre for Tropical Diseases, Ho Chi Minh City, Viet Nam., VinhChau NV, Vinh NN, Hung NT, Phung MQ, Toan LM, Mai PP, Dung NT, HoaiTam DT, Arnold K |
| المصدر: | Annals of the Academy of Medicine, Singapore [Ann Acad Med Singap] 1997 Sep; Vol. 26 (5), pp. 659-63. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academy Of Medicine, Singapore Country of Publication: Singapore NLM ID: 7503289 Publication Model: Print Cited Medium: Print ISSN: 0304-4602 (Print) Linking ISSN: 03044602 NLM ISO Abbreviation: Ann Acad Med Singap Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Singapore : Academy Of Medicine, Singapore Original Publication: Singapore. |
| مواضيع طبية MeSH: | Artemisinins*, Malaria/*drug therapy , Malaria/*epidemiology, Antimalarials/therapeutic use ; Clinical Trials as Topic ; Drug Resistance, Multiple ; Humans ; Mefloquine/therapeutic use ; Sesquiterpenes/therapeutic use ; Vietnam/epidemiology |
| مستخلص: | Malaria is still the most common infectious cause of mortality and morbidity in Viet Nam as it is in many developing countries in the tropics. The presence of resistance to available antimalarials and compliance in the target population are factors that influence the choice of drugs and regimens. In order to develop an ideal treatment for malaria, we conducted several clinical trials in patients with the disease in different settings. The results of these trials suggest that a combination of single dose artemisinin (or its derivatives) and mefloquine is the most effective, safe and practical treatment for acute non-complicated malaria due to multidrug-resistant Plasmodium falciparum. Concerning severe and complicated malaria, parenteral or rectal multi-doses of artemisinin or analogues are recommended due to their rapid parasite clearance time and other possible anti-cytoadherence effects. With its rapid parasite clearance, very early treatment of uncomplicated cases with artemisinin (and derivatives), especially at a health post level may help to prevent the development of complications, consequently reducing the number of severe cases and the malaria mortality rate. |
| Number of References: | 16 |
| المشرفين على المادة: | 0 (Antimalarials) 0 (Artemisinins) 0 (Sesquiterpenes) 9RMU91N5K2 (artemisinin) TML814419R (Mefloquine) |
| تواريخ الأحداث: | Date Created: 19980312 Date Completed: 19980414 Latest Revision: 20210915 |
| رمز التحديث: | 20240628 |
| PMID: | 9494675 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0304-4602 |
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