دورية أكاديمية
The alpha5beta1 integrin mediates elimination of amyloid-beta peptide and protects against apoptosis.
| العنوان: | The alpha5beta1 integrin mediates elimination of amyloid-beta peptide and protects against apoptosis. |
|---|---|
| المؤلفون: | Matter ML; La Jolla Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA., Zhang Z, Nordstedt C, Ruoslahti E |
| المصدر: | The Journal of cell biology [J Cell Biol] 1998 May 18; Vol. 141 (4), pp. 1019-30. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 0375356 Publication Model: Print Cited Medium: Print ISSN: 0021-9525 (Print) Linking ISSN: 00219525 NLM ISO Abbreviation: J Cell Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York : Rockefeller University Press |
| مواضيع طبية MeSH: | Cell Adhesion*, Amyloid beta-Peptides/*metabolism , Apoptosis/*physiology , Peptide Fragments/*metabolism , Receptors, Fibronectin/*physiology, Amyloid beta-Peptides/isolation & purification ; Amyloid beta-Peptides/pharmacology ; Animals ; Apoptosis/drug effects ; CHO Cells ; Cell Line ; Cell Survival/drug effects ; Cricetinae ; Flow Cytometry ; Humans ; Kinetics ; Neuroblastoma ; Peptide Fragments/isolation & purification ; Peptide Fragments/pharmacology ; Receptors, Fibronectin/biosynthesis ; Recombinant Proteins/biosynthesis ; Transfection ; Tumor Cells, Cultured |
| مستخلص: | The amyloid-beta peptide (Abeta) can mediate cell attachment by binding to beta1 integrins through an arg-his-asp sequence. We show here that the alpha5beta1 integrin, a fibronectin receptor, is an efficient binder of Abeta, and mediates cell attachment to nonfibrillar Abeta. Cells engineered to express alpha5beta1 internalized and degraded more added Abeta1-40 than did alpha5beta1-negative control cells. Deposition of an insoluble Abeta1-40 matrix around the alpha5beta1-expressing cells was reduced, and the cells showed less apoptosis than the control cells. Thus, the alpha5beta1 integrin may protect against Abeta deposition and toxicity, which is a course of Alzheimer's disease lesions. |
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| معلومات مُعتمدة: | CA 30199 United States CA NCI NIH HHS; CA28896 United States CA NCI NIH HHS; P30 CA030199 United States CA NCI NIH HHS; CA09579 United States CA NCI NIH HHS; T32 CA009579 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Amyloid beta-Peptides) 0 (Peptide Fragments) 0 (Receptors, Fibronectin) 0 (Recombinant Proteins) 0 (amyloid beta-protein (1-40)) |
| تواريخ الأحداث: | Date Created: 19980620 Date Completed: 19980617 Latest Revision: 20240214 |
| رمز التحديث: | 20240214 |
| مُعرف محوري في PubMed: | PMC2132763 |
| DOI: | 10.1083/jcb.141.4.1019 |
| PMID: | 9585419 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0021-9525 |
|---|---|
| DOI: | 10.1083/jcb.141.4.1019 |