التفاصيل البيبلوغرافية
| العنوان: |
Influence of thrombus components in mediating Staphylococcus aureus adhesion to polyurethane surfaces. |
| المؤلفون: |
Baumgartner JN; Department of Chemical Engineering, University of Delaware, College of Engineering, Newark 19716, USA., Cooper SL |
| المصدر: |
Journal of biomedical materials research [J Biomed Mater Res] 1998 Jun 15; Vol. 40 (4), pp. 660-70. |
| نوع المنشور: |
Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Wiley Country of Publication: United States NLM ID: 0112726 Publication Model: Print Cited Medium: Print ISSN: 0021-9304 (Print) Linking ISSN: 00219304 NLM ISO Abbreviation: J Biomed Mater Res Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Hoboken, N.J. [etc.] Wiley. |
| مواضيع طبية MeSH: |
Polyurethanes*, Bacterial Adhesion/*physiology , Staphylococcus aureus/*physiology , Thrombosis/*blood , Thrombosis/*microbiology, Humans ; Materials Testing ; Microscopy, Electron, Scanning ; Microscopy, Video ; Platelet Adhesiveness ; Staphylococcus aureus/cytology ; Surface Properties ; Thrombosis/pathology |
| مستخلص: |
The role of protein and cellular components of thrombi in mediating bacterial adhesion on artificial surfaces was investigated in this study. The attachment of Staphylococcus aureus on polyurethane surfaces was observed directly using an automated video microscopy system. Surfaces were preconditioned with components of platelet-fibrin thrombi, including fibrinogen, thrombin, plasma, and isolated platelets. Experiments were performed in a radial flow chamber, and attachment rate constants were compared on the preconditioned surfaces in an effort to understand the complex relationship that exists between bacterial infection and thrombosis on synthetic biomaterials. Preadsorption of fibrinogen to surfaces significantly increased S. aureus adhesion compared to those preadsorbed with albumin alone while the presence of fibrin dramatically increased bacterial attachment compared to plasma preadsorbed surfaces. While the presence of adherent platelets also increased bacterial attachment, fibrin appeared to play a larger role in mediating bacterial adhesion on polyurethane surfaces. Striking results were obtained on the zwitterionic phosphonated polyurethane for a number of pretreatment conditions with regard to decreased bacterial adhesion and fibrinogen deposition. |
| المشرفين على المادة: |
0 (Polyurethanes) |
| تواريخ الأحداث: |
Date Created: 19980523 Date Completed: 19980923 Latest Revision: 20190909 |
| رمز التحديث: |
20231215 |
| DOI: |
10.1002/(sici)1097-4636(19980615)40:4<660::aid-jbm18>3.0.co;2-j |
| PMID: |
9599043 |
| قاعدة البيانات: |
MEDLINE |
