دورية أكاديمية
The relationship of ischemia-reperfusion injury of transplanted lung and the up-regulation of major histocompatibility complex II on host peripheral lymphocytes.
| العنوان: | The relationship of ischemia-reperfusion injury of transplanted lung and the up-regulation of major histocompatibility complex II on host peripheral lymphocytes. |
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| المؤلفون: | Qayumi AK; Department of Surgery, University of Brisith Columbia, Vancouver Hospital and Health Sciences Centre, The British Columbia Transplant Society, Canada., Nikbakht-Sangari MN, Godin DV, English JC, Horley KJ, Keown PA, Lim SP, Ansley DM, Koehle MS |
| المصدر: | The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 1998 May; Vol. 115 (5), pp. 978-89. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mosby Country of Publication: United States NLM ID: 0376343 Publication Model: Print Cited Medium: Print ISSN: 0022-5223 (Print) Linking ISSN: 00225223 NLM ISO Abbreviation: J Thorac Cardiovasc Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: St. Louis, MO : Mosby Original Publication: St. Louis. |
| مواضيع طبية MeSH: | Lung Transplantation*, HLA-DR Antigens/*metabolism , Reperfusion Injury/*metabolism , T-Lymphocytes/*metabolism, Animals ; CD3 Complex/metabolism ; Follow-Up Studies ; Graft Rejection/immunology ; Graft Rejection/metabolism ; Graft Rejection/pathology ; Immunocompromised Host ; Immunohistochemistry ; Interleukin-10/metabolism ; Lymphocyte Activation/immunology ; Organ Preservation ; Reperfusion Injury/immunology ; Reperfusion Injury/pathology ; Respiratory Function Tests ; Superoxide Dismutase/metabolism ; Swine ; T-Lymphocytes/pathology ; Up-Regulation |
| مستخلص: | Objectives: This study was designed to examine the relationship between ex vivo preservation time of the transplanted lung and the extent of injury and to relate this to the severity of rejection with and without allogenicity. Methods: Single lung transplantation was performed on two groups of domestic swine. Group A (n = 7) and group B (n = 6) had ex vivo preservation times of 4 and 15 hours, respectively, at 4 degrees C hypothermia. Group C (n = 6) underwent 2 hours of warm ischemia via dissection and isolation of the left lung with ligation of its bronchial artery and crossclamping of the left pulmonary artery, vein, and bronchus without explantation. Assessment measures included lung function, antioxidant enzyme activities in the plasma and lung tissue, levels of inflammatory mediators in the recipient plasma, and quantification of major histocompatibility complex II HLA-DR-beta on host peripheral lymphocytes. Results: All groups demonstrated increases in interleukin-10, lung weight, and HLA-DR-1beta expression and decreases in lung-tissue antioxidant enzyme activities, gas exchange, and lung compliance. There was a strong positive correlation between ex vivo preservation time and the expression of HLA-DR-beta and a negative correlation between ischemic time and lung-tissue superoxide dismutase. Conclusions: These results suggest that the intensity of the host immunogenic response is related to the severity of ischemia-reperfusion injury and is independent of tissue incompatibility and/or the type of ischemic insult. We conclude that the extension of ex vivo preservation time may predispose the transplanted lung to more severe rejection. |
| المشرفين على المادة: | 0 (CD3 Complex) 0 (HLA-DR Antigens) 130068-27-8 (Interleukin-10) EC 1.15.1.1 (Superoxide Dismutase) |
| تواريخ الأحداث: | Date Created: 19980530 Date Completed: 19980616 Latest Revision: 20190914 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/s0022-5223(98)70395-2 |
| PMID: | 9605065 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0022-5223 |
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| DOI: | 10.1016/s0022-5223(98)70395-2 |