تقرير
DNA compression caused by an upstream point mutation.
| العنوان: | DNA compression caused by an upstream point mutation. |
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| المؤلفون: | Weinshenker BG; Mayo Clinic/Mayo Foundation, Rochester, MN 55905, USA., Hebrink DD, Gacy AM, McMurray CT |
| المصدر: | BioTechniques [Biotechniques] 1998 Jul; Vol. 25 (1), pp. 68-72. |
| نوع المنشور: | Research Support, Non-U.S. Gov't; Technical Report |
| اللغة: | English |
| بيانات الدورية: | Publisher: Future Science Country of Publication: England NLM ID: 8306785 Publication Model: Print Cited Medium: Print ISSN: 0736-6205 (Print) Linking ISSN: 07366205 NLM ISO Abbreviation: Biotechniques Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London, UK : Future Science Original Publication: [Natick, MA : Eaton Pub. Co., c1983- |
| مواضيع طبية MeSH: | Antigens, CD/*genetics , DNA/*chemistry , Point Mutation/*genetics , Receptors, Tumor Necrosis Factor/*genetics, Base Sequence ; DNA/drug effects ; DNA/genetics ; DNA Primers ; Deoxyguanine Nucleotides/chemistry ; Deoxyguanine Nucleotides/pharmacology ; Nucleic Acid Conformation/drug effects ; Receptors, Tumor Necrosis Factor, Type I |
| مستخلص: | We observed an apparent series of insertions and deletions beginning 5 bp downstream of an A-->G silent transition in exon 1 of the tumor necrosis factor receptor 1 gene. The apparent sequence anomaly was observed only in individuals carrying the transition. Formamide gel electrophoresis revealed that the apparent sequence anomaly was due to compression. The compression is plausibly explained by a hairpin in the reaction products in a region of trinucleotide CAG repeats. One should suspect the presence of DNA compression when a series of deletions and insertions follows a single base pair mutation that leads to a series of trinucleotide repeats. |
| المشرفين على المادة: | 0 (Antigens, CD) 0 (DNA Primers) 0 (Deoxyguanine Nucleotides) 0 (Receptors, Tumor Necrosis Factor) 0 (Receptors, Tumor Necrosis Factor, Type I) 101515-08-6 (2'-deoxy-7-deazaguanosine triphosphate) 9007-49-2 (DNA) |
| تواريخ الأحداث: | Date Created: 19980721 Date Completed: 19981007 Latest Revision: 20180928 |
| رمز التحديث: | 20240628 |
| DOI: | 10.2144/98251st01 |
| PMID: | 9668978 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 0736-6205 |
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| DOI: | 10.2144/98251st01 |