التفاصيل البيبلوغرافية
| العنوان: |
Somatostatin receptor expression in multiple endocrine neoplasia and in von Hippel-Lindau disease. |
| المؤلفون: |
Lamberts SW; Department of Medicine, Erasmus University Rotterdam, The Netherlands. lamberts@inw3.azr.nl, Hofland LJ, Lely AJ, de Herder WW |
| المصدر: |
Journal of internal medicine [J Intern Med] 1998 Jun; Vol. 243 (6), pp. 569-71. |
| نوع المنشور: |
Journal Article; Review |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8904841 Publication Model: Print Cited Medium: Print ISSN: 0954-6820 (Print) Linking ISSN: 09546820 NLM ISO Abbreviation: J Intern Med Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Oxford : Blackwell Scientific Publications, c1989- |
| مواضيع طبية MeSH: |
Gene Expression Regulation, Neoplastic*, Multiple Endocrine Neoplasia/*metabolism , Receptors, Somatostatin/*biosynthesis , von Hippel-Lindau Disease/*metabolism, Humans |
| مستخلص: |
Somatostatin receptors are expressed on the majority of neuroendocrine tumours. The presence of these receptors is clinically useful. First, long-term treatment with somatostatin analogues controls hormonal hypersecretion, which controls flushing attacks, watery diarrhoea, hypoglycaemia and electrolyte disorders in patients with carcinoids and islet cell tumours. Secondly, somatostatin receptor imaging is used to localize primary neuroendocrine tumours and to visualize the spread of the disease. Thirdly internalization of somatostatin receptors by primary neuroendocrine tumours opens the possibility of carrying out radio- and chemotherapy with somatostatin analogues coupled to beta-emitting radionuclides and chemotherapeutic drugs. The presence and role of somatostatin receptors on the tumours which occur in multiple endocrine neoplasia and von Hippel-Lindau disease are discussed. |
| Number of References: |
21 |
| المشرفين على المادة: |
0 (Receptors, Somatostatin) |
| تواريخ الأحداث: |
Date Created: 19980729 Date Completed: 19980813 Latest Revision: 20190905 |
| رمز التحديث: |
20231215 |
| DOI: |
10.1046/j.1365-2796.1998.00340.x |
| PMID: |
9681860 |
| قاعدة البيانات: |
MEDLINE |
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