دورية أكاديمية
Fertility problems and breast cancer risk in young women: a case-control study in the United States.
| العنوان: | Fertility problems and breast cancer risk in young women: a case-control study in the United States. |
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| المؤلفون: | Weiss HA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7374, USA., Troisi R, Rossing MA, Brogan D, Coates RJ, Gammon MD, Potischman N, Swanson CA, Brinton LA |
| المصدر: | Cancer causes & control : CCC [Cancer Causes Control] 1998 May; Vol. 9 (3), pp. 331-9. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 9100846 Publication Model: Print Cited Medium: Print ISSN: 0957-5243 (Print) Linking ISSN: 09575243 NLM ISO Abbreviation: Cancer Causes Control Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Dordrecht : Kluwer Academic Publishers Original Publication: Oxford, UK : Rapid Communications of Oxford Ltd., 1990- |
| مواضيع طبية MeSH: | Maternal Age*, Breast Neoplasms/*etiology , Infertility/*complications, Adult ; Breast Neoplasms/epidemiology ; Case-Control Studies ; Female ; Humans ; Middle Aged ; Pregnancy ; Risk Factors ; United States/epidemiology |
| مستخلص: | Objectives: Late age at first birth and nulliparity are established risk factors for breast cancer, yet the extent to which fertility problems contribute to these associations remains largely unexplored. Here, we examine self-reported fertility problems as a risk factor for breast cancer in young women. Methods: We used a population-based case-control study of 2,173 cases and 1,990 controls aged 20 to 54 years in the United States. Structured in-person interviews were used to elicit detailed information on established and potential breast cancer risk factors. Information was collected on pregnancy details, including difficulties becoming pregnant or maintaining a pregnancy. Results: Self-reported difficulty in becoming pregnant or maintaining a pregnancy was reported by 450 cases and 377 controls. Overall, there was little association between these fertility problems and risk of breast cancer (odds ratio [OR] = 1.05). Parity was associated with a decreased risk of breast cancer in women both with (OR = 0.71) and without (OR = 0.79) fertility problems. There was little evidence of an increased risk of breast cancer with later age at first full-term birth among women without fertility problems (ORage 35+ :age <20 = 1.13, 95 percent confidence interval [CI] = 0.7-1.9), but a relatively strong association among women with fertility problems (ORage 35+ :age <20 = 2.96, CI = 1.3-7.0). Among women with a first full-term birth at age 35 or older, fertility problems were associated with a twofold risk of breast cancer. Analyses of duration of unprotected sexual intercourse prior to first pregnancy as an alternative estimate of infertility produced similar results. Conclusions: Our study suggests that the association between late age at first birth and breast cancer is stronger among women with self-reported fertility problems than among women with no fertility problems. |
| تواريخ الأحداث: | Date Created: 19980731 Date Completed: 19980924 Latest Revision: 20191024 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1023/a:1008881305738 |
| PMID: | 9684713 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 0957-5243 |
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| DOI: | 10.1023/a:1008881305738 |