دورية أكاديمية
Donor and recipient family histories of hypertension influence renal impairment and blood pressure during acute rejections.
| العنوان: | Donor and recipient family histories of hypertension influence renal impairment and blood pressure during acute rejections. |
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| المؤلفون: | Guidi E; Centro di Ricerca Clinical in Nefrologia e Ipertensione Arteriosa, Unità Operativa di Nefrologia, Dialisi e Terapia del Tranpianto Renale, Ospedale Niguarda Ca'Granda, Milano, Italy., Cozzi MG, Minetti E, Bianchi G |
| المصدر: | Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 1998 Nov; Vol. 9 (11), pp. 2102-7. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wolters Kluwer Health, on behalf of the American Society of Nephrology Country of Publication: United States NLM ID: 9013836 Publication Model: Print Cited Medium: Print ISSN: 1046-6673 (Print) Linking ISSN: 10466673 NLM ISO Abbreviation: J Am Soc Nephrol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : Hagerstown, MD : Wolters Kluwer Health, on behalf of the American Society of Nephrology Original Publication: Baltimore, MD : Williams & Wilkins, c1990- |
| مواضيع طبية MeSH: | Kidney Transplantation* , Tissue Donors*, Blood Pressure/*physiology , Graft Rejection/*physiopathology , Hypertension/*genetics , Hypertension/*physiopathology , Kidney/*physiopathology, Acute Disease ; Cohort Studies ; Double-Blind Method ; Graft Rejection/pathology ; Humans ; Kidney/pathology ; Prospective Studies |
| مستخلص: | A previous historical prospective observational study, double blinded for knowledge of kidney donors' family history of hypertension, included 85 transplanted patients with stable renal function, not treated with cyclosporine, who were followed-up for an average of 8 yr and carefully characterized for the presence or absence of hypertension in the donor and recipient families. The recipients without a family history of hypertension, but grafted with a kidney coming from a "hypertensive" family, developed hypertension much more frequently than recipients grafted with a kidney coming from a "normotensive" family, or recipients with familial hypertension in whom the origin of the kidney did not influence the prevalence of hypertension after transplantation. In this second study of the same patients, it was found that these recipients with a "normotensive" family and a "hypertensive" kidney showed a greater increase of diastolic BP (P = 0.005) and a greater degree of acute renal damage (P = 0.004) during acute rejections than all of the other recipients. This extension study shows that a grafted kidney can transmit not only chronic hypertension, but also susceptibility to a greater rise in BP and more severe kidney impairment after an acute insult. |
| تواريخ الأحداث: | Date Created: 19981110 Date Completed: 19990119 Latest Revision: 20210518 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1681/ASN.V9112102 |
| PMID: | 9808097 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1046-6673 |
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| DOI: | 10.1681/ASN.V9112102 |