دورية أكاديمية
Degradation of double-walled polymer microspheres of PLLA and P(CPP:SA)20:80. II. In vivo degradation.
| العنوان: | Degradation of double-walled polymer microspheres of PLLA and P(CPP:SA)20:80. II. In vivo degradation. |
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| المؤلفون: | Leach KJ; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island 02912, USA., Takahashi S, Mathiowitz E |
| المصدر: | Biomaterials [Biomaterials] 1998 Nov; Vol. 19 (21), pp. 1981-8. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print Cited Medium: Print ISSN: 0142-9612 (Print) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <1995-> : Amsterdam : Elsevier Science Original Publication: [Guilford, England] : IPC Science and Technology Press, 1980- |
| مواضيع طبية MeSH: | Implants, Experimental*, Biocompatible Materials/*pharmacokinetics , Decanoic Acids/*pharmacokinetics , Lactic Acid/*pharmacokinetics , Polyesters/*pharmacokinetics , Polymers/*pharmacokinetics, Animals ; Biocompatible Materials/chemistry ; Calorimetry, Differential Scanning ; Decanoic Acids/chemistry ; Drug Carriers ; Ethylene Oxide ; Lactic Acid/chemistry ; Microscopy, Electron, Scanning ; Microspheres ; Molecular Weight ; Polyesters/chemistry ; Polymers/chemistry ; Rats ; Rats, Sprague-Dawley ; Spectroscopy, Fourier Transform Infrared ; Sterilization |
| مستخلص: | Double-walled (DW) polymer microspheres with a core of poly(1,3-bis-(p-carboxyphenoxy propane)-co-(sebacic anhydride)20:80 (P(CPP:SA)20:80) and an external coat of poly(L-lactic acid) (PLLA) were implanted subcutaneously and intramuscularly and were allowed to degrade for up to 6 months. The tissue surrounding the implant was fixed and sectioned for histological evaluation by light and scanning electron microscopy. The remaining polymer was extracted with chloroform and analyzed by gel permeation chromatography (G PC), Fourier-transform infrared (FTIR) spectroscopy, and differential scanning calorimetry (DSC). The inner core of the more hydrolytically labile P(CPP:SA)20:80 degraded first, becoming more granular over time. The PLLA coating showed no changes morphologically. The DW microspheres induced a stronger inflammatory response during the first week than did the SW PLLA microspheres, but this resolved by the second week. The SW PLLA microspheres showed no changes by SEM or optical microscopy. No differences in degradation were seen between samples implanted subcutaneously and those implanted intramuscularly. In vivo degradation was correlated to the results of an in vitro degradation study published as the first paper in this two paper series. |
| المشرفين على المادة: | 0 (Biocompatible Materials) 0 (Decanoic Acids) 0 (Drug Carriers) 0 (Polyesters) 0 (Polymers) 33X04XA5AT (Lactic Acid) 459TN2L5F5 (poly(lactide)) 90409-78-2 (decanedioic acid-4,4'-(1,3-propanediylbis(oxy))bis(benzoic acid) copolymer) JJH7GNN18P (Ethylene Oxide) |
| تواريخ الأحداث: | Date Created: 19981224 Date Completed: 19990302 Latest Revision: 20190815 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/s0142-9612(98)00109-4 |
| PMID: | 9863532 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0142-9612 |
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| DOI: | 10.1016/s0142-9612(98)00109-4 |