دورية أكاديمية
Acetazolamide vasoreactivity in vascular dementia: a positron emission tomographic study.
| العنوان: | Acetazolamide vasoreactivity in vascular dementia: a positron emission tomographic study. |
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| المؤلفون: | De Reuck J; PET Centre UZ/RUG, Gent University, Gent, Belgium. jdereuck@allserv.rug.ac.be, Decoo D, Hasenbroekx MC, Lamont B, Santens P, Goethals P, Strijckmans K, Lemahieu I |
| المصدر: | European neurology [Eur Neurol] 1999 Jan; Vol. 41 (1), pp. 31-6. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 0150760 Publication Model: Print Cited Medium: Print ISSN: 0014-3022 (Print) Linking ISSN: 00143022 NLM ISO Abbreviation: Eur Neurol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, New York, Karger. |
| مواضيع طبية MeSH: | Tomography, Emission-Computed*, Acetazolamide/*pharmacology , Cerebrovascular Circulation/*drug effects , Dementia, Vascular/*diagnostic imaging , Vasodilator Agents/*pharmacology , Vasomotor System/*drug effects, Aged ; Aged, 80 and over ; Ammonia ; Brain Ischemia/complications ; Brain Ischemia/diagnostic imaging ; Dementia, Multi-Infarct/diagnostic imaging ; Dementia, Multi-Infarct/etiology ; Dementia, Multi-Infarct/physiopathology ; Dementia, Vascular/etiology ; Dementia, Vascular/physiopathology ; Female ; Humans ; Male ; Microcirculation/drug effects ; Middle Aged ; Nitrogen Radioisotopes ; Risk Factors ; Vasodilation/drug effects ; Vasomotor System/physiopathology |
| مستخلص: | The present study investigates the vasoreactivity of the brain in patients with large infarcts and dementia (multi-infarct dementia; MID) and in patients with microangiopathy, lacunes, white matter changes and dementia (lacunar dementia; LD) using positron emission tomography (PET) and 13NH3 as regional cerebral blood flow (rCBF) tracer. In the control group, an increase in rCBF ranging from 32 to 43% was found in all brain regions after intravenous acetazolamide administration. In both the MID group and the group with multiple infarcts without dementia, moderate loss of vasoreactivity was observed in the frontal, temporal and parietal cortex compared to the control values. Vasoreactivity was severely impaired in all cerebral regions of the LD group and restricted to the thalamus in the group with lacunes and white matter changes without dementia (lacunar stroke; LS). This suggests that global loss of vasoreactivity is not a determining factor in the occurrence of MID, but might be important in LD. The present study shows that loss of the vascular reserve leading to exhausted metabolic reserve of the whole brain is one of the possible mechanisms for the occurrence of vascular dementia. |
| المشرفين على المادة: | 0 (Nitrogen Radioisotopes) 0 (Vasodilator Agents) 7664-41-7 (Ammonia) O3FX965V0I (Acetazolamide) |
| تواريخ الأحداث: | Date Created: 19990114 Date Completed: 19990322 Latest Revision: 20180213 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1159/000007995 |
| PMID: | 9885326 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0014-3022 |
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| DOI: | 10.1159/000007995 |