دورية أكاديمية
Immunologic and histologic observations in reovirus-induced otitis media in the mouse.
| العنوان: | Immunologic and histologic observations in reovirus-induced otitis media in the mouse. |
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| المؤلفون: | Meek RB 3rd; Department of Otolaryngology-Head and Neck Surgery, West Virginia University School of Medicine, Morganstown 26506, USA., McGrew BM, Cuff CF, Berrebi AS, Spirou GA, Wetmore SJ |
| المصدر: | The Annals of otology, rhinology, and laryngology [Ann Otol Rhinol Laryngol] 1999 Jan; Vol. 108 (1), pp. 31-8. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Country of Publication: United States NLM ID: 0407300 Publication Model: Print Cited Medium: Print ISSN: 0003-4894 (Print) Linking ISSN: 00034894 NLM ISO Abbreviation: Ann Otol Rhinol Laryngol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Los Angeles : Sage Original Publication: St. Louis : Annals Publishing Co |
| مواضيع طبية MeSH: | Otitis Media/*etiology , Otitis Media/*immunology , Reoviridae Infections/*complications , Reoviridae Infections/*immunology, Animals ; Antibodies, Viral/immunology ; Antigens, Viral/immunology ; B-Lymphocytes/immunology ; Disease Models, Animal ; Ear, Middle/immunology ; Ear, Middle/pathology ; Eustachian Tube/immunology ; Eustachian Tube/pathology ; Mice ; Mice, Inbred BALB C ; Nasopharynx/immunology ; Nasopharynx/pathology ; T-Lymphocytes/immunology |
| مستخلص: | The goals of this study were to develop a mouse model for virally induced otitis media, and to study the immune response to infection. Intranasal inoculation of mice by reovirus was used to induce otitis media. Immunohistochemical evidence for the presence of reovirus in the nasopharynx, eustachian tubes, and middle ears and the amount of infiltrating B-cells and T-cells in those sites were serially evaluated by painlessly sacrificing animals over a 21 -day period. Reovirus antigen was detected in the middle ear mucosa by day 4 in 75% of infected animals, and histologic evidence for otitis media was found in 54% of all infected animals. A significant increase in B-cells in the nasopharynx and eustachian tubes was noted 7 to 10 days following infection. The number of infiltrating T-cells did not vary significantly from that in the control animals at any of the sites. These results provide a basis for further investigations of the immune response in otitis media. |
| معلومات مُعتمدة: | AI34544 United States AI NIAID NIH HHS; DC02266 United States DC NIDCD NIH HHS |
| المشرفين على المادة: | 0 (Antibodies, Viral) 0 (Antigens, Viral) |
| تواريخ الأحداث: | Date Created: 19990204 Date Completed: 19990222 Latest Revision: 20170214 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1177/000348949910800105 |
| PMID: | 9930538 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0003-4894 |
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| DOI: | 10.1177/000348949910800105 |