التفاصيل البيبلوغرافية
| العنوان: |
The application of high-throughput screening to novel lead discovery. |
| المؤلفون: |
Kenny BA; Cambridge Drug Discovery, Cambridge, UK., Bushfield M, Parry-Smith DJ, Fogarty S, Treherne JM |
| المصدر: |
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques [Prog Drug Res] 1998; Vol. 51, pp. 245-69. |
| نوع المنشور: |
Journal Article; Review |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Birkhäuser Verlag Country of Publication: Switzerland NLM ID: 1304021 Publication Model: Print Cited Medium: Print ISSN: 0071-786X (Print) Linking ISSN: 0071786X NLM ISO Abbreviation: Prog Drug Res Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Basel, Birkhäuser Verlag. |
| مواضيع طبية MeSH: |
Drug Design*, Drug Evaluation, Preclinical/*methods, Animals ; Humans |
| مستخلص: |
The ability to discover new lead compounds for novel therapeutic targets is a pivotal step in drug discovery programmes. High-throughput screening (HTS) utilises a number of platforms for the rapid screening of novel targets to accelerate this process. Key issues in HTS include assay configuration and the ability of a high-throughput screen to predict drug-target interactions accurately. This review highlights a number of issues in the HTS process and describes three key target areas that are likely to be sources of novel, therapeutically important drugs. Particular emphasis is placed on the mechanistic basis of drug-target interactions that are of prime importance in the design of HTS approaches. Critical aspects of information management related to HTS are summarised. |
| Number of References: |
52 |
| تواريخ الأحداث: |
Date Created: 19990209 Date Completed: 19990224 Latest Revision: 20191102 |
| رمز التحديث: |
20240627 |
| DOI: |
10.1007/978-3-0348-8845-5_7 |
| PMID: |
9949864 |
| قاعدة البيانات: |
MEDLINE |
