التفاصيل البيبلوغرافية
| العنوان: |
Evaluating the Individualized Treatment of Traditional Chinese Medicine: A Pilot Study of N-of-1 Trials. |
| المؤلفون: |
Haiyin Huang, Peilan Yang, Jingjing Xue, Jie Tang, Liyu Ding, Ying Ma, JieWang, Guyatt, Gordon H., Vanniyasingam, Thuva, Yuqing Zhang |
| المصدر: |
Evidence-based Complementary & Alternative Medicine (eCAM); 2014, Vol. 2014, p1-10, 10p, 2 Diagrams, 2 Charts |
| مصطلحات موضوعية: |
BRONCHIECTASIS, CONFIDENCE intervals, CROSSOVER trials, DIFFERENTIAL diagnosis, HERBAL medicine, CASE studies, CHINESE medicine, RESEARCH funding, PILOT projects, RANDOMIZED controlled trials, VISUAL analog scale, TREATMENT effectiveness, BLIND experiment, DRUG administration, DRUG dosage |
| مستخلص: |
Purpose. To compare the efficacy of individualized herbal decoction with controlled decoction for individual patients with stable bronchiectasis. Methods. We conducted N-of-1 RCTs (single-patient, double-blind, randomized, multiple crossover design) in 3 patients with stable bronchiectasis. The primary outcome was patient self-rated symptom scores on visual analogue scales. Secondary outcome was 24-hour sputum volume. A clinical efficacy criterion which combined symptoms score and medication preference was also formulated. Results. All three patients showed various degrees of improvement on their symptoms and one patient's (Case 3) 24 h sputum volume decreased from 70mL to 30 mL. However, no significant differences were found between individualized herbal decoction and control decoction on symptoms score, or on 24-hour sputum volume. One patient (Case 2) had clear preference for the individualized herbal decoction over the standard one with the confirmation after unblinding. We therefore considered this case as clinically important. Discussion. N-of-1 trials comply with individualized philosophy of TCM clinical practice and had good compliance. It is necessary to set up clinical efficacy criteria and to consider the interference of acute exacerbation. [ABSTRACT FROM AUTHOR] |
|
Copyright of Evidence-based Complementary & Alternative Medicine (eCAM) is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder