التفاصيل البيبلوغرافية
| العنوان: |
The Effect of Resveratrol on Surgery-Induced Epidural Fibrosis in Laminectomy Rats. |
| المؤلفون: |
Peifeng Sun, Bo Miao, Hongmei Xin, Jinzhu Zhao, Guofeng Xia, Peng Xu, Jian Hu, Zhenfeng Li, Jianmin Li |
| المصدر: |
Evidence-based Complementary & Alternative Medicine (eCAM); 2014, Vol. 2014, p1-6, 6p, 2 Color Photographs, 2 Charts, 2 Graphs |
| مصطلحات موضوعية: |
PHYTOTHERAPY, RESVERATROL, ANALYSIS of variance, ANIMAL experimentation, FACTOR analysis, IMMUNOHISTOCHEMISTRY, LAMINECTOMY, RATS, RNA, FIBROSIS, BLIND experiment, DATA analysis software, DESCRIPTIVE statistics, THERAPEUTICS |
| مستخلص: |
Epidural fibrosis (EF) is a common complication for the patients who underwent laminectomy. Recently, EF is thought to cause recurrent postoperative pain after laminectomy. Resveratrol has been shown to exert its anti-inflammatory, antifibrotic, and antiproliferative multifaceted properties. The object of this study was to investigate the effects of resveratrol on the prevention of postlaminectomy EF formation in laminectomy rats. A controlled double-blinded study was performed on 60 healthy adult Sprague-Dawley rats that underwent lumbar laminectomy at the L1-L2 levels.They were divided randomly into 3 groups (1, 2, and 3) of 20 rats each--group 1: resveratrol treatment group; group 2: resveratrol dilution saline treatment group; group 3: shamgroup (rats underwent laminectomy without treatment). All rats were killed 4 weeks after operation. The Rydell score, hydroxyproline content, vimentin cells density, fibroblasts density, and inflammatory factors expressional levels all suggested better results in resveratrol group than the other two groups. Resveratrol is able to inhibit fibroblasts proliferation, and TGF-β1 and IL-6 expressions and prevent epidural fibrosis in postlaminectomy rat. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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