التفاصيل البيبلوغرافية
| العنوان: |
Rhinitis in the first 18 months of life: Exploring the role of respiratory viruses. |
| المؤلفون: |
Hardjojo, Antony, Goh, Anne, Shek, Lynette P.C., Van Bever, Hugo P. S., Teoh, Oon Hoe, Soh, Jian Yi, Thomas, Biju, Tan, Boon Huan, Chan, Yiong Huak, Ramamurthy, Mahesh Babu, Goh, Daniel Y. T., Soh, Shu ‐ E, Saw, Seang ‐ Mei, Kwek, Kenneth, Chong, Yap ‐ Seng, Godfrey, Keith M., Gluckman, Peter D., Lee, Bee Wah |
| المصدر: |
Pediatric Allergy & Immunology; Feb2015, Vol. 26 Issue 1, p25-33, 9p |
| مصطلحات موضوعية: |
RHINITIS, ALLERGIC rhinitis, ALLERGENS, RESPIRATORY infections, QUESTIONNAIRES |
| مستخلص: |
Background: Rhinitis is common in early childhood, but allergic rhinitis is considered a later manifestation of the atopic march. This study aimed to evaluate rhinitis (allergic and non-allergic) in the first 18 months of life, its link with other atopic manifestations and the role of respiratory viruses. Methods: Subjects (n = 1237) of the Singapore GUSTO birth cohort were followed up quarterly until 18 months of age with questionnaires to screen for rhinitis symptoms lasting at least 2 wk and with monthly calls to positive subjects to detect prolonged/ recurrent rhinitis symptoms (total duration ⩾4 wk). Anterior nasal swabbing for molecular-based virus detection was conducted during these visits and near (within a month) rhinitis episodes. Skin prick testing to common environmental and food allergens was conducted at the 18 month visit. Results: Prolonged/recurrent rhinitis was significantly associated with history of parental atopy (mother: aOR = 2.17; father: aOR = 1.82) and atopic comorbidities of eczema (aOR = 2.53) and wheeze (aOR = 4.63) (p < 0.05), though not with allergen sensitization. Although the frequency of nasal respiratory virus detection during scheduled quarterly visits did not differ between prolonged/recurrent rhinitis and matched controls (p > 0.05), virus detection was higher in swabs obtained within a month following rhinitis episodes in prolonged/recurrent rhinitis subjects compared with scheduled visits (adjusted p = 0.04). Conclusions: Based on the duration of rhinitis symptoms, this study defined a subset of early childhood rhinitis which was associated with atopic predisposition and comorbidities. Persistent respiratory viral shedding may contribute to the symptomatology. Whether this entity is a precursor of subsequent childhood allergic rhinitis will require longer follow-up. [ABSTRACT FROM AUTHOR] |
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