التفاصيل البيبلوغرافية
| العنوان: |
The Protective Effect of EtOAc Extract from Gastrodia elata on Oxidative Damage of PC12 Cells. |
| المؤلفون: |
HAN, Chunni, YAN, Hanwen, WEN, Jinlong, LIN, Qing, DUAN, Xiaohua |
| المصدر: |
Medicinal Plant; May2014, Vol. 5 Issue 5, p9-17, 5p |
| مصطلحات موضوعية: |
GASTRODIA elata, THERAPEUTIC use of plant extracts, OXIDATIVE stress, ANTIOXIDANTS, ISCHEMIA treatment, CELL morphology, THERAPEUTICS |
| مستخلص: |
[Objective] The purpose of this study was to investigate the effects and possible mechanisms of EtOAc extract from Gastrodia elata on oxidative damage of PC12 cells induced by H2O2. [Methods] PC12 cells were cultured and exposed to H2O2 to establish oxidative damage model. The protective effect of EtOAc extract was observed by morphological identification, colorimetric MTT assay, leakage rate of LDH, intracellular ROS level and T-SOD activity. [Results] Compared with the model group, EtOAc extract from Gastrodia elata could improve the cells morphology significantly, increase the survival rate of 14.7% (P<0.01), decrease the ROS level (P<0.01) and the release of LDH (P <0. 01) from cells into culture medium, raise intracellular T-SOD activity (P <0. 01). [Conclusions] EtOAc extract from Gastrodia elata had obviously antioxidant effect in vitro. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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