التفاصيل البيبلوغرافية
| العنوان: |
Stent treatment of malignant gastric outlet obstruction: the effect on rate of gastric emptying, symptoms, and survival. |
| المؤلفون: |
Larssen L, Hauge T, Medhus AW, Larssen, Lene, Hauge, Truls, Medhus, Asle W |
| المصدر: |
Surgical Endoscopy & Other Interventional Techniques; Oct2012, Vol. 26 Issue 10, p2955-2960, 6p |
| مستخلص: |
Background: Advanced pancreatic cancer and other malignancies located proximal to the small bowel might cause gastric outlet obstruction (GOO) resulting in nausea, vomiting, dehydration, and malnutrition. Self-expandable metal stents (SEMS) to a large extent have replaced surgical treatment, with gastro-entero-anastomosis as palliative treatment for GOO. The aim of the present study was to evaluate the effect of duodenal stenting on the rate of gastric emptying, symptoms, and survival.Methods: Patients with endoscopically verified malignant obstruction of the proximal duodenum were included. Gastric emptying rate was measured prior to and within 1 week after stent placement using a meal containing (13)C-octanoic acid as a marker. Symptoms related to GOO were assessed by the patients before and 2 weeks after stent treatment and during the gastric emptying tests. All patients were followed up until death.Results: In the patients included (n = 17), all studied variables of gastric emptying improved significantly following treatment, and a reduction in self-reported obstructive symptoms was observed. There was no correlation between survival and the rate of gastric emptying before or after, or the change in the rate of emptying.Conclusion: The present study demonstrated that treatment with SEMS results in improved gastric emptying in most patients with GOO and a corresponding reduction in self-reported obstruction symptoms. However, survival and emptying were not related. The present findings provide further evidence that treatment with stents is an effective palliative treatment in patients with GOO. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
