التفاصيل البيبلوغرافية
| العنوان: |
Nutritional impact of antipseudomonas intravenous antibiotic courses in cystic fibrosis. |
| المؤلفون: |
Vic P, Ategbo S, Gottrand F, Launay V, Loeuille GA, Elian JC, Druon D, Farriaux JP, Turck D, Vic, P, Ategbo, S, Gottrand, F, Launay, V, Loeuille, G A, Elian, J C, Druon, D, Farriaux, J P, Turck, D |
| المصدر: |
Archives of Disease in Childhood; May1997, Vol. 76 Issue 5, p437-440, 4p |
| مستخلص: |
Objective: To evaluate the short term effects on nutritional status of home intravenous anti-pseudomonas antibiotic courses in cystic fibrosis (CF) patients chronically colonised with Pseudomonas aeruginosa.Design: A prospective study involving 38 CF patients, mean age 10.9 (SD 4.3) years (range 4.3 to 22.2 years), presenting with pulmonary exacerbations of P aeruginosa infection. The patients received a 14 day antibiotic course of intravenous ceftazidime (200 mg/kg/day) and either amikacin (35 mg/kg/day) or tobramycin (15 mg/kg/day). Nutritional evaluation on days 1 and 14 involved measurements of weight, weight/height ratio (per cent of predicted value), energy intake (per cent of recommended daily allowances), serum prealbumin, and body composition assessed by two methods: bioelectrical analysis (BIA) and skinfold anthropometry. The non-parametric Wilcoxon t test was used for statistical analysis, with a Bland-Altman plot to assess the degree of agreement between the two methods of evaluating body composition.Results: Weight increased by 1.0 (0.8) kg (p < 0.001); weight/height increased from 94.4(12.2)% to 98(12.7)% (p < 0.001), energy intake from 107(32)% to 119(41)% (p < 0.02), and prealbumin from 183 (63) to 276 (89) mg/l (p < 0.001). Fat mass increased by 0.8 (1.0) kg (p < 0.001), without any significant change in fat-free mass. The limits of agreement between BIA and anthropometry were -0.7 kg and +1.1 kg.Conclusions: Antibiotic courses allow an improvement in nutritional status in CF patients, with a gain in fat mass. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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