التفاصيل البيبلوغرافية
| العنوان: |
Human induced pluripotent stem cells labeled with luorescent magnetic nanoparticles for targeted imaging and hyperthermia therapy for gastric cancer. |
| المؤلفون: |
Chao Li, Jing Ruan, Meng Yang, Fei Pan, Guo Gao, Su Qu, You-Lan Shen, Yong-Jun Dang, Kan Wang, Wei-Lin Jin, Da-Xiang Cui |
| المصدر: |
Cancer Biology & Medicine; Sep2015, Vol. 12 Issue 3, p163-174, 14p |
| مصطلحات موضوعية: |
PLURIPOTENT stem cells, THERMOTHERAPY, STOMACH cancer treatment, THERAPEUTICS |
| مستخلص: |
Objective: Human induced pluripotent stem (iPS) cells exhibit great potential for generating functional human cells for medical therapies. In this paper, we report for use of human iPS cells labeled with fluorescent magnetic nanoparticles (FMNPs) for targeted imaging and synergistic therapy of gastric cancer cells in vivo. Methods: Human iPS cells were prepared and cultured for 72 h. The culture medium was collected, and then was co- incubated with MGC803 cells. Cell viability was analyzed by the MTT method. FMNP-labeled human iPS cells were prepared and injected into gastric cancer-bearing nude mice. he mouse model was observed using a small-animal imaging system. he nude mice were irradiated under an external alternating magnetic field and evaluated using an infrared thermal mapping instrument. Tumor sizes were measured weekly. Results: iPS cells and the collected culture medium inhibited the growth of MGC803 cells. FMNP-labeled human iPS cells targeted and imaged gastric cancer cells in vivo, as well as inhibited cancer growth in vivo through the external magnetic field. Conclusion: FMNP-labeled human iPS cells exhibit considerable potential in applications such as targeted dual-mode imaging and synergistic therapy for early gastric cancer. [ABSTRACT FROM AUTHOR] |
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