التفاصيل البيبلوغرافية
| العنوان: |
RELIABILITY ANALYSIS ATTEMPT FOR POINT MUTATIONS IN DNA REPLICATION. |
| المؤلفون: |
MIHALA, Adrian, ŞECLĂMAN, Edward, VELICESCU, Corneliu, PACUREANU, Liliana, SIMON, Zeno, URSONIU, Sorin, MANG, Niculina, ANGHEL, Andrei |
| المصدر: |
Annals of West University of Timisoara: Series of Biology; 2015, Vol. 18 Issue 1, p27-32, 6p |
| مصطلحات موضوعية: |
ESCHERICHIA coli, DNA replication, POINT mutation (Biology), DNA repair, DNA polymerases, MECHANICAL chemistry |
| مستخلص: |
A reliability analysis attempt is hereby presented for point mutations in Escherichia coli DNA replication without considering the postreplicative correction by the DNA mismatch repair system. Rates for correct and false enzymatic and mechanochemical processes are considered for calculation of probabilities for false primary inclusion of deoxynucleotides in the growing DNA chain and for defective verification of the new formed base pair in this chain by the DNA polymerase complex. Formulae for obtaining correct new synthesized DNA strand are given. The probability of no false insertion in the entire helix of length N in a correct new DNA strand is calculated to 0.63 with the 10-5 and 10-2 figures for the probabilities of defective base inclusion and escape rate and 4.6·106 bp length of the K12 strain E. coli chromosome. Perspectives of reliability analysis for mechanism concerning specificity in biologic processes are discussed. [ABSTRACT FROM AUTHOR] |
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