التفاصيل البيبلوغرافية
| العنوان: |
Effective Exercise Modality to Reduce Insulin Resistance in Women With Type 2 Diabetes. |
| المؤلفون: |
Cuff, Darcye J., Meneilly, Graydon S., Martin, Alan, Ignaszewski, Andrew, Tildesley, Hugh D., Frohlich, Jiri J. |
| المصدر: |
Diabetes Care; Nov2003, Vol. 26 Issue 11, p2977-2982, 6p, 2 Charts |
| مصطلحات موضوعية: |
EXERCISE, INSULIN resistance, DIABETES in women |
| مستخلص: |
OBJECTIVE — The purpose of this study was to evaluate whether a combined resistance and aerobic training program would improve insulin sensitivity compared with aerobic training alone in postmenopausal women with type 2 diabetes. A second objective was to relate the improved insulin sensitivity to changes in abdominal adipose tissue (AT) and thigh muscle density. RESEARCH DESIGN AND METHODS — A total of 28 obese postmenopausal women with type 2 diabetes were randomly assigned to one of three 16-week treatments: control, aerobic only training (Ae only), or aerobic plus resistance training (Ae+RT). Pre- and posttreatment outcome measures included glucose disposal by hyperinsulinemic-euglycemic clamp and computed tomography scans of abdominal AT and mid-thigh skeletal muscle. RESULTS — Glucose infusion rates increased significantly (P < 0.05) in the Ae+RT group. Both exercise groups had reduced abdominal subcutaneous and visceral AT and increased muscle density. The Ae+RT training group exhibited a significantly greater increase in muscle density than the Ae only group. Improved glucose disposal was independently associated with changes in subcutaneous AT, visceral AT, and muscle density. Muscle density retained a relationship with glucose disposal after controlling for abdominal AT. CONCLUSIONS — Adding resistance training to aerobic training enhanced glucose disposal in postmenopausal women with type 2 diabetes. The improved insulin sensitivity is related to loss of abdominal subcutaneous and visceral AT and to increased muscle density. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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