التفاصيل البيبلوغرافية
| العنوان: |
MicroRNA-203 suppresses gastric cancer growth by targeting PIBF1/Akt signaling. |
| المؤلفون: |
Shao-Jun Chu, Ge Wang, Peng-Fei Zhang, Rui Zhang, Yan-Xia Huang, Yun-Min Lu, Wei Da, Qun Sun, Jing Zhang, Jin-Shui Zhu |
| المصدر: |
Journal of Experimental & Clinical Cancer Research (17569966); 3/15/2016, Vol. 35, p1-11, 11p |
| مصطلحات موضوعية: |
MICRORNA, TUMOR growth, DEVELOPMENTAL biology, ONCOLOGY, CARCINOGENS |
| مستخلص: |
Background: MicroRNAs (miRNAs) have been proved involved in many tumorigenic behaviors including tumor growth. But, the clinical significance and functions of miRNA-203 in gastric cancer (GC) remain elusive. Results: Decreased expression of miRNA-203 was correlated with tumor size, poor prognosis and recurrence in GC patients. Overexpression of miR-203 or knockdown of its target progesterone immunomodulatory binding factor 1 (PIBF1) inhibited GC growth in vitro and in vivo, while miR-203 knockdown promoted GC proliferation. In addition, PIBF1 overexpression attenuated the inhibitory effects of miR-203 on GC growth and enhanced that effect on p-Akt expression. Conclusions: MiR-203 as a tumor biomarker suppresses GC growth through targeting the PIBF1/Akt signaling, suggesting that it may have the important therapeutic potential for the treatment of GC. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Experimental & Clinical Cancer Research (17569966) is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Find this article in full text from Springer Verlag. 
Full Text Finder