التفاصيل البيبلوغرافية
العنوان: |
MicroRNA-203 suppresses gastric cancer growth by targeting PIBF1/Akt signaling. |
المؤلفون: |
Shao-Jun Chu, Ge Wang, Peng-Fei Zhang, Rui Zhang, Yan-Xia Huang, Yun-Min Lu, Wei Da, Qun Sun, Jing Zhang, Jin-Shui Zhu |
المصدر: |
Journal of Experimental & Clinical Cancer Research (17569966); 3/15/2016, Vol. 35, p1-11, 11p |
مصطلحات موضوعية: |
MICRORNA, TUMOR growth, DEVELOPMENTAL biology, ONCOLOGY, CARCINOGENS |
مستخلص: |
Background: MicroRNAs (miRNAs) have been proved involved in many tumorigenic behaviors including tumor growth. But, the clinical significance and functions of miRNA-203 in gastric cancer (GC) remain elusive. Results: Decreased expression of miRNA-203 was correlated with tumor size, poor prognosis and recurrence in GC patients. Overexpression of miR-203 or knockdown of its target progesterone immunomodulatory binding factor 1 (PIBF1) inhibited GC growth in vitro and in vivo, while miR-203 knockdown promoted GC proliferation. In addition, PIBF1 overexpression attenuated the inhibitory effects of miR-203 on GC growth and enhanced that effect on p-Akt expression. Conclusions: MiR-203 as a tumor biomarker suppresses GC growth through targeting the PIBF1/Akt signaling, suggesting that it may have the important therapeutic potential for the treatment of GC. [ABSTRACT FROM AUTHOR] |
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قاعدة البيانات: |
Complementary Index |