التفاصيل البيبلوغرافية
| العنوان: |
Tracheobronchopathia Osteochondroplastica: a rare case report of a non-smoker and non-atopic patient, with a long history of wheezing since childhood. |
| المؤلفون: |
Fois, Alessandro G., Arcadu, Antonella, Santoru, Luigi, Trisolini, Rocco, Marras, Vincenzo, Ginesu, Giorgio C., Canu, Sara, Cordero, Lorenzo, Diana, Gabriella, Pirina, Pietro |
| المصدر: |
Multidisciplinary Respiratory Medicine; 4/19/2016, p1-5, 5p |
| مصطلحات موضوعية: |
RARE diseases, TRACHEAL diseases, ASTHMA diagnosis, PSEUDOMONAS aeruginosa infections, WHEEZE, RESPIRATORY organ sounds, DIAGNOSIS |
| مستخلص: |
Background: Tracheobronchopathia Osteochondroplastica (TBPO) is an uncommon and benign condition characterized by osseous or metaplastic cartilaginous 1-3 mm nodules in the submucosa of the tracheobronchial tree. Posterior membranous wall of trachea is typically spared. Ecchondrosis and exostosis nodules can cause chronic inflammation and mucosal metaplasia, stiffness and airway obstruction. The prevalence of this disease, often asymptomatic or associated with nonspecific symptoms, is underestimated, and the mean age at diagnosis is 50 years. Case presentation: We report a case of a 49 year old male, non-smoker. He was a smith, homeless, born in Romania and reported a diagnosis of asthma since childhood. He was admitted to our Respiratory Unit presenting low-grade fever with profuse sweating, cough, purulent sputum, and ground-glass opacity with irregularity in main bronchi detected by High-Resolution Computed Tomography (HRCT) scan. Fibrobronchoscopy revealed the presence of mucosal irregularities up to the segmental bronchi entrance. Histological examination showed nodules of osseouscartilaginous nature, consistent with TBPO. Microbiological tests of Bronchoalveolar Lavage fluid also revealed an infection by Pseudomonas Aeruginosa. Conclusion: TBPO is a rare disease characterized by wheezing, cough, hemoptysis, and recurrent pulmonary infections, with typical onset during adulthood. In the case reported, the symptoms began in childhood, although they had been misinterpreted as asthma. Even if childhood-onset is not reported in literature, it is likely that small changes occur in the first few years of life and become more evident in adulthood. The involvement of segmental and sub-segmental bronchi, usually spared in TBPO, could explain the presence of wheezing and non-productive cough reported by our patient since childhood. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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