التفاصيل البيبلوغرافية
| العنوان: |
Susceptible and protective associations of HLA DRB1*/ DQB1* alleles and haplotypes with ischaemic stroke. |
| المؤلفون: |
Murali, V., Rathika, C., Ramgopal, S., Padma Malini, R., Arun Kumar, M. J., Neethi Arasu, V., Jeyaram Illiayaraja, K., Balakrishnan, K. |
| المصدر: |
International Journal of Immunogenetics; Jun2016, Vol. 43 Issue 3, p159-165, 7p |
| مصطلحات موضوعية: |
STROKE, MORTALITY, ATHEROSCLEROSIS, HUMAN leucocytes, ALLELES, ANTIGEN synthesis |
| مستخلص: |
Stroke has emerged as the second commonest cause of mortality worldwide and is a major public health problem. For the first time, we present here the association of human leucocyte antigen ( HLA)- DRB1*/ DQB1* alleles and haplotypes with ischaemic stroke in South Indian patients. Ischaemic stroke ( IS) cases and controls were genotyped for HLA- DRB1*/ DQB1* alleles by polymerase chain reaction sequence-specific primers ( PCR- SSP) method. The frequencies of HLA class II alleles such as DRB1*04, DRB1*07, DRB1*11, DRB1*12, DRB1*13, DQB1*02 and DQB1*07 were high in IS patients than in the age- and gender-matched controls, suggesting that the individuals with these alleles are susceptible to ischaemic stroke in South India. The frequencies of alleles such as DRB1*03, DRB1*10, DRB1*14, DQB1*04 and DQB1*05 were less in IS cases than in the controls, suggesting a protective association. Haplotypes DRB1*04- DQB1*0301, DRB1*07- DQB1*02, DRB1*07- DQB1*0301, DRB1*11- DQB1*0301 and DRB1*13- DQB1*06 were found to be high in IS patients conferring susceptibility. The frequency of haplotype DRB1*10- DQB1*05 was high in controls conferring protection. IS- LVD and gender-stratified analysis too confirmed these susceptible and protective associations. Thus, HLA- DRB1*/ DQB1* alleles and haplotypes strongly predispose South Indian population to ischaemic stroke. Further studies in different populations with large sample size or the meta-analysis are needed to explain the exact mechanism of associations of HLA gene(s) with IS. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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