التفاصيل البيبلوغرافية
| العنوان: |
Blocking the phosphatidylinositol 3-kinase pathway inhibits neuregulin-1-mediated rescue of neurotoxicity induced by Aβ1-42. |
| المؤلفون: |
Baik, Tai‐Kyoung, Kim, Young‐Jung, Kang, Se‐Mi, Song, Dae‐Yong, Min, Sun Seek, Woo, Ran‐Sook |
| المصدر: |
Journal of Pharmacy & Pharmacology; Aug2016, Vol. 68 Issue 8, p1021-1029, 9p |
| مصطلحات موضوعية: |
NEUREGULINS, NEUROPROTECTIVE agents, NEUROTOXICOLOGY, LACTATE dehydrogenase, REACTIVE oxygen species |
| مستخلص: |
Objectives Neuregulin-1 ( NRG1) has an important role in both the development and the plasticity of the brain as well as neuroprotective properties. In this study, we investigated the downstream pathways of NRG1 signalling and their role in the prevention of Aβ1-42-induced neurotoxicity. Methods Lactate dehydrogenase ( LDH) release, reactive oxygen species ( ROS) generation, superoxide dismutase ( SOD) activity and TUNEL staining were assayed to examine the neuroprotective properties in primary rat cortical neurons. Key findings The inhibition of PI3K/Akt activation abolished the ability of NRG1 to prevent Aβ1-42-induced LDH release and increased TUNEL-positive cell count and reactive oxygen species accumulation in primary cortical neurons. Conclusions Our results demonstrate that NRG1 signalling exerts a neuroprotective effect against Aβ1-42-induced neurotoxicity via activation of the PI3K/Akt pathway. Furthermore, this suggests that NRG1 has neuroprotective potential for the treatment of AD. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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