التفاصيل البيبلوغرافية
| العنوان: |
Association between the vitamin D receptor gene polymorphism and osteoporosis. |
| المؤلفون: |
JU WU, DE-PENG SHANG, SHENG YANG, DA-PENG FU, HAO-YI LING, SHUANG-SHUANG HOU, JIAN-MIN LU |
| المصدر: |
Biomedical Reports; Aug2016, Vol. 5 Issue 2, p233-236, 4p |
| مصطلحات موضوعية: |
VITAMIN D receptors, GENETIC polymorphisms, OSTEOPOROSIS genetics, OSTEOPOROSIS diagnosis, BONE density, CALCIUM regulating hormones |
| مستخلص: |
The influence of the vitamin D receptor (VDR) gene for the risk of osteoporosis remains to be elucidated. The aim of the present study was to understand the distribution of various single-nucleotide polymorphisms (SNPs) within the VDR gene and its association with the risk of osteoporosis. In total, 378 subjects without a genetic relationship were recruited to the study between January 2013 and July 2015. The subjects were divided into three groups, which were the normal (n=234), osteoporosis (n=65) and osteoporosis with osteoporotic fracture (n=79) groups. Three pertinent SNPs of the VDR gene rs17879735 (ApaI, Allele A/a, SNP C>A) were examined with polymerase chain reaction-restriction fragment length polymorphism. The bone mineral density (BMD) of the lumbar spine (L2-L4), femoral neck, Ward's and Tro was measured using dual-energy X-ray absorptiometry. The distributions of genotype frequencies aa, AA and Aa were 48.68, 42.86 and 8.46%, separately. Following analysis of each site, BMD, body mass index (BMI) and age, BMD for each site was negatively correlated with age (P<0.01) and positively correlated with BMI (P<0.01). Correction analysis revealed that there were significant differences in the Ward's triangle BMD among each genotype (P<0.05), in which the aa genotype exhibited the lower BMD (P<0.05). No significant difference was identified among the different genotypes in the occurrence of osteoporosis with osteoporotic fracture (P>0.05). In conclusion, these indicated that the VDR gene ApaI polymorphisms had an important role in the osteoporosis risk. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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