التفاصيل البيبلوغرافية
| العنوان: |
Differential effects of once-weekly glucagon-like peptide-1 receptor agonist dulaglutide and metformin on pancreatic β-cell and insulin sensitivity during a standardized test meal in patients with type 2 diabetes. |
| المؤلفون: |
Mari, A., Del Prato, S., Ludvik, B., Milicevic, Z., Peña, A., Shurzinske, L., Karanikas, C. A., Pechtner, V. |
| المصدر: |
Diabetes, Obesity & Metabolism; Aug2016, Vol. 18 Issue 8, p834-839, 6p |
| مصطلحات موضوعية: |
GLUCAGON-like peptide-1 agonists, METFORMIN, PHYSIOLOGICAL effects of hypoglycemic agents, TYPE 2 diabetes treatment, DRUG dosage, C-peptide, INSULIN research, PANCREATIC beta cells |
| مستخلص: |
This substudy of the AWARD-3 trial evaluated the effects of the once-weekly glucagon-like peptide-1 receptor agonist, dulaglutide, versus metformin on glucose control, pancreatic function and insulin sensitivity, after standardized test meals in patients with type 2 diabetes. Meals were administered at baseline, 26 and 52 weeks to patients randomized to monotherapy with dulaglutide 1.5 mg/week (n = 133), dulaglutide 0.75 mg/week (n = 136), or metformin ≥1500 mg/day (n = 140). Fasting and postprandial serum glucose, insulin, C-peptide and glucagon levels were measured up to 3 h post-meal. β-cell function and insulin sensitivity were assessed using empirical variables and mathematical modelling. At 26 weeks, similar decreases in area under the curve for glucose [ AUCglucose (0-3 h)] were observed among all groups. β-cell function [ AUCinsulin/ AUCglucose (0-3 h)] increased with dulaglutide and was unchanged with metformin (p ≤ 0.005, both doses). Dulaglutide improved insulin secretion rate at 9 mmol/l glucose (p ≤ 0.04, both doses) and β-cell glucose sensitivity (p = 0.004, dulaglutide 1.5 mg). Insulin sensitivity increased more with metformin versus dulaglutide. In conclusion, dulaglutide improves postprandial glycaemic control after a standardized test meal by enhancing β-cell function, while metformin exerts a greater effect on insulin sensitivity. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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