التفاصيل البيبلوغرافية
| العنوان: |
PRESENCE OF HUMAN BOCAVIRUS 1 IN HOSPITALISED CHILDREN WITH ACUTE RESPIRATORY TRACT INFECTIONS IN LATVIA AND LITHUANIA. |
| Alternate Title: |
CILVĒKA BOKAVĪRUSA 1 KLĀTBŪTNE LATVIJĀ UN LIETUVĀ HOSPITALIZĒTIEM BĒRNIEM AR AKŪTĀM ELPCEĻU SLIMĪBĀM. (Latin) |
| المؤلفون: |
Nora-Krūkle, Zaiga, Rasa, Santa, Vilmane, Anda, Grāvelsina, Sabīne, Kālis, Mārtiņš, Ziemele, Inga, Naciute, Milda, Petraitiene, Sigita, Mieliauskaite, Diana, Klimantaviciene, Migle, Girkontaite, Irute, Hsin-Fu Liu, Jih-Hui Lin, Yung-Cheng Lin, Hsiu-Chuan Chan, Gardovska, Dace, Murovska, Modra |
| المصدر: |
Proceedings of the Latvian Academy of Sciences. Section B: Natural, Exact & Applied Sciences; Aug2016, Vol. 70 Issue 4, p198-204, 7p |
| مصطلحات موضوعية: |
PARVOVIRUS diseases, ETIOLOGY of diseases, PEDIATRIC respiratory diseases, POLYMERASE chain reaction, CLADISTIC analysis |
| مصطلحات جغرافية: |
LATVIA, LITHUANIA |
| Abstract (English): |
Human bocavirus 1 (HBoVI) is a parvovirus recently found to be a possible aetiologic agent of acute respiratory disease in children. We conducted the first clinical and molecular study on this virus in Latvia (LV) and Lithuania (LT). The aim of the study was to determine the occurrence of HBoV1 in respiratory tract samples taken from hospitalised children with acute respiratory tract infections in LVand LT. In total 186 children with age one to 50 months, and who fulfilled criteria of acute respiratory tract infection, including lower respiratory tract infections, with or without fever, were included in this study. A nasopharyngeal aspirate was obtained from each patient on admission. DNA was isolated and polimerase chain reaction (PCR) performed targeting the HBoV1 NS1sequence. HBoV1 positive samples were sequenced and phylogenetic analysis was performed. HBoV1 sequence was detected in 42 (32%) of 130 LV and in 8 (14%) of 56 LT samples. In LV the majority of patients with HBoV1 infection were observed in February while in LT in October. The phylogenetic tree for HBoV1 indicated that isolates of HBoV1 cluster closely and include almost all of the isolates in this study. HBoV1 is common in Latvia and Lithuania and might be a significant pathogen that contributes to acute respiratory tract infections in children. [ABSTRACT FROM AUTHOR] |
| Abstract (Latin): |
Pirmā tipa cilvēka bokavīruss (HBoV1) ir parvovīruss, kas tiek uzskatīts par iespējamu etioloģisku faktoru akūtu respiratoru slimību gadījumā bērniem. Mēs veicām pirmo klīnisko un molekulāro pētījumu par HBoV1 infekcijas sastopamību Latvijā (LV) un Lietuvā (LT). Raksta mērķis bija noskaidrot HBoV1 klātbūtni respiratorā trakta paraugos, kas iegūti no hospitalizētiem bērniem ar akūtām elpceļu slimībām LV un LT. Pētījumā iekļauti 186 hospitalizēti bērni vecumā no 1 līdz 50 mēnešiem ar akūtām elpceļu slimībām. Tika iegūts nazofaringeālā aspirāta paraugs bērna pirmajā stacionēšanas dienā, izolēta DNS un noteikta HBoV1 NS1 sekvences klātbūtne, lietojot polimerāzes ķēdes reakciju. Pozitīvie HBoV1 paraugi sekvencēti un veikta filoģenētiskā analīze. HBoV1 konstatēja 42 (32%) no 130 LV un 8 (14%) no 56 LT paraugos. Latvijā HBoV1 biežāk atrada paraugos, kas ņemti februārī, bet Lietuvā -- oktobrī. Filoģenētiskā analīze parādīja, ka HBoV1 izolāti ir cieši radniecīgi viens otram. HBoV1 cirkulē Latvijā un Lietuvā un, iespējams, ir nozīmīgs patogēns, kas iesaistīts akūtu elpceļu infekciju izraisīšanā bērniem. [ABSTRACT FROM AUTHOR] |
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