التفاصيل البيبلوغرافية
| العنوان: |
Synthesis and antibacterial activity of some novel piperazinophanes with an intraannular ester functionality. |
| المؤلفون: |
Selvarani, Sivasamy, Rajakumar, Perumal |
| المصدر: |
New Journal of Chemistry; Nov2016, Vol. 40 Issue 11, p9494-9499, 6p |
| مصطلحات موضوعية: |
BACTERIAL genetics, ESCHERICHIA coli, PARAOXONASE kinetics, MANNICH reaction, ESTERS analysis, CYCLOPHANE derivatives |
| مستخلص: |
1 : 1 and 2 : 2 oligomeric piperazinophanes with an intraannular ester functionality have been synthesized via Mannich reaction of various aromatic esters with piperazine by a one-pot reaction under benign conditions through the multicomponent reaction methodology. The newly synthesized piperazinophanes were characterized using spectral and analytical methods. The ester based 1 : 1 oligomeric piperazinophanes exhibit good target binding ability in molecular docking studies and also show better antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Streptococcus pyogenes bacteria than the 2 : 2 oligomeric piperazinophanes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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