التفاصيل البيبلوغرافية
| العنوان: |
Cervical cytological abnormalities and human papilloma virus infection in women infected with HIV in Southern India. |
| المؤلفون: |
Thunga, Suchitra, Andrews, Anusmitha, Ramapuram, John, Satyamoorthy, Kapaettu, Kini, Hema, Unnikrishnan, B., Adhikari, Prabha, Singh, Prakhar, Kabekkodu, Shama Prasada, Bhat, Samatha, Kadam, Anagha, Shetty, Avinash K |
| المصدر: |
Journal of Obstetrics & Gynaecology Research; Dec2016, Vol. 42 Issue 12, p1822-1828, 7p, 3 Charts |
| مصطلحات موضوعية: |
CERVICAL intraepithelial neoplasia, CERVIX uteri diseases, CYTOLOGY, DYSPLASIA, EPITHELIAL cells, HIV-positive persons, PAP test, PAPILLOMAVIRUS diseases, PAPILLOMAVIRUSES, DISEASE prevalence, CROSS-sectional method, DESCRIPTIVE statistics, CD4 lymphocyte count, DISEASE risk factors |
| مصطلحات جغرافية: |
INDIA |
| مستخلص: |
Aim The aim of this study was to examine the association between CD4 count, human papilloma virus (HPV) infection, and the risk of cervical intraepithelial neoplasia among HIV-infected women. Methods A cross-sectional study was conducted among 104 HIV-infected women attending an antiretroviral therapy clinic. They underwent Pap smear and cervical HPV DNA testing. Results The overall prevalence of HPV infection was 57.7%. HPV 16 was the commonest genotype found (38.5%); HPV 16 and 18 put together contributed to 73.3% of HPV infection; 27.5% of HIV-infected women had squamous cell abnormalities. Cervical intraepithelial neoplasia was less likely among women with CD4 count > 500/mm3 (12%) and in those without opportunistic infections (17.8%). The prevalence of high-risk HPV infection was higher in women with high-grade squamous intraepithelial lesions or greater lesions (85.7%) as compared to women with normal cytology (52.1%). Conclusion The high prevalence of HPV infection and cervical intraepithelial neoplasia in HIV-infected women warrants the need for regular Pap smear screening in these women and routine HPV vaccination for adolescents to reduce the burden of cervical cancer in India. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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