التفاصيل البيبلوغرافية
| العنوان: |
Pharmacological evaluation of a selective bradykinin B1 antagonist in a canine model of arthritis. |
| المؤلفون: |
Duclos, B. A., Rugg, C. A., White, J., Ross, J. T., Darling, M., Huczek, D., Curry, J., Alexander‐Bowman, S., Townley, A., Garcia‐Tapia, D., Chio, C., Kamerling, S. |
| المصدر: |
Journal of Veterinary Pharmacology & Therapeutics; Jan2017, Vol. 40 Issue 1, p70-76, 7p |
| مصطلحات موضوعية: |
VETERINARY pharmacology, NONSTEROIDAL anti-inflammatory agents, LABORATORY dogs, ANIMAL models of inflammation, LIGANDS (Biochemistry), THERAPEUTICS |
| مستخلص: |
The effects of a selective bradykinin 1 receptor antagonist, compound A, were evaluated in a canine model of acute inflammatory model of arthritis. Despite detection of the B1 receptor in canine type B synoviocytes using a fluorescent ligand, oral administration of compound A (9 and 27 mg/kg) did not improve weight bearing of dogs injected intra-articularly with IL-1 β in a force plate analysis. Analysis of the synovial fluid of IL-1 β-treated dogs indicated high levels of bradykinin postchallenge. Excellent exposure, coupled with evidence of the presence of the B1 receptor during an acute inflammatory model of pain, indicates an inability of the receptor to mediate inflammatory pain in canines. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Veterinary Pharmacology & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder