التفاصيل البيبلوغرافية
| العنوان: |
Statistical evaluation of the Fixed Concentration Procedure for acute inhalation toxicity assessment. |
| المؤلفون: |
Stallard, Nigel, Whitehead, Anne, Indans, Ian |
| المصدر: |
Human & Experimental Toxicology; Nov2003, Vol. 22 Issue 11, p575-585, 11p, 2 Diagrams, 5 Charts |
| مصطلحات موضوعية: |
TOXICOLOGY of poisonous gases, TOXICITY testing, PROOF & certification of death, DIE-off (Zoology) |
| مستخلص: |
The conventional method for the assessment of acute inhalation toxicity (OECD Test Guideline 403, 1981) uses death of animals as an endpoint to identify the median lethal concentration (LC[sub 50]). A new OECD Testing Guideline called the Fixed Concentration Procedure (FCP) is being prepared to provide an alternative to Test Guideline 403. Unlike Test Guideline 403, the FCP does not provide a point estimate of the LC[sub 50], but aims to identify an airborne exposure level that causes clear signs of nonlethal toxicity. This is then used to assign classification according to the new Globally Harmonized System of Classification and Labelling scheme (GHS). The FCP has been validated using statistical simulation rather than by in vivo testing. The statistical simulation approach predicts the GHS classification outcome and the numbers of deaths and animals used in the test for imaginary substances with a range of LC[sub 50] values and dose response curve slopes. This paper describes the FCP and reports the results from the statistical simulation study assessing its properties. It is shown that the procedure will be completed with considerably less death and suffering than Test Guideline 403, and will classify substances either in the same or a more stringent GHS class than that assigned on the basis of the LC[sub 50] value. [ABSTRACT FROM AUTHOR] |
|
Copyright of Human & Experimental Toxicology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder