التفاصيل البيبلوغرافية
| العنوان: |
Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice. |
| المؤلفون: |
Ryo Koizumi, Kazuo Azuma, Hironori Izawa, Minoru Morimoto, Kosuke Ochi, Takeshi Tsuka, Tomohiro Imagawa, Tomohiro Osaki, Norihiko Ito, Yoshiharu Okamoto, Hiroyuki Saimoto, Shinsuke Ifuku |
| المصدر: |
International Journal of Molecular Sciences; Feb2017, Vol. 18 Issue 2, p279, 11p |
| مصطلحات موضوعية: |
NANOFIBERS, CHITIN, CHITOSAN, MUCOSITIS, INTESTINAL disease treatment, LABORATORY mice, MICE physiology, THERAPEUTICS |
| مستخلص: |
This study investigated the prophylactic effects of orally administered surface-deacetylated chitin nanofibers (SDACNFs) and chitosan against 5-fluorouracil (5-FU)-induced intestinal mucositis, which is a common side effect of 5-FU chemotherapy. SDACNFs and chitosan abolished histological abnormalities associated with intestinal mucositis and suppressed hypoproliferation and apoptosis of intestinal crypt cells. These results indicate that SDACNF and chitosan are useful agents for preventing mucositis induced by anti-cancer drugs. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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