التفاصيل البيبلوغرافية
| العنوان: |
Oral bioavailability enhancement of flubendazole by developing nanofibrous solid dosage forms. |
| المؤلفون: |
Vigh, Tamás, Démuth, Balázs, Balogh, Attila, Galata, Dorián L., Van Assche, Ivo, Mackie, Claire, Vialpando, Monica, Van Hove, Ben, Psathas, Petros, Borbás, Enikő, Pataki, Hajnalka, Boeykens, Peter, Marosi, György, Verreck, Geert, Nagy, Zsombor K. |
| المصدر: |
Drug Development & Industrial Pharmacy; Jul2017, Vol. 43 Issue 7, p1126-1133, 8p |
| مصطلحات موضوعية: |
ANTHELMINTICS, SOLID dosage forms, ORAL medication, POVIDONE, BIOAVAILABILITY |
| مستخلص: |
The bioavailability of the anthelminthic flubendazole was remarkably enhanced in comparison with the pure crystalline drug by developing completely amorphous electrospun nanofibres with a matrix consisting of hydroxypropyl-β-cyclodextrin and polyvinylpyrrolidone. The thus produced formulations can potentially be active against macrofilariae parasites causing tropical diseases, for example, river blindness and elephantiasis, which affect altogether more than a hundred million people worldwide. The bioavailability enhancement was based on the considerably improved dissolution. The release of a dose of 40 mg could be achieved within 15 min. Accordingly, administration of the nanofibrous system ensured an increased plasma concentration profile in rats in contrast to the practically non-absorbable crystalline flubendazole. Furthermore, easy-to-grind fibers could be developed, which enabled compression of easily administrable immediate release tablets. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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