التفاصيل البيبلوغرافية
| العنوان: |
Antibacterial, anti-inflammatory and antioxidant effects of acetyl-11-α-keto-β-boswellic acid mediated silver nanoparticles in experimental murine mastitis. |
| المؤلفون: |
Yegireddy Muralidhar, Mekapogu Alpha Raj, Tollamadugu NagaVenkata KrishanVara Prasad, Kumar, Thota Venkata Chaitanya, Kaliki Adilaxmamma, Chinthamaneni Srilatha, Rao, G. Sreeenivasa, Pothireddy Sreevani, Nagireddy Aparna |
| المصدر: |
IET Nanobiotechnology (Wiley-Blackwell); 2017, Vol. 11 Issue 6, p682-689, 8p, 2 Color Photographs, 2 Charts, 5 Graphs |
| مصطلحات موضوعية: |
ANTIBACTERIAL agents, SILVER nanoparticles, ANTIOXIDANTS, CHEMICAL inhibitors, MASTITIS, OXIDATIVE stress |
| مستخلص: |
Mastitis is an important economic disease causing production losses in dairy industry. Antibiotics are becoming ineffective in controlling mastitis due to the emergence of resistant strains requiring the development of novel therapeutic agents. In this study, the authors present the phytochemical synthesis of silver nanoparticles (AgNPs) with acetyl-11-α-keto-β- boswellic acid and evaluation of their activity in Staphylococcus aureus induced murine mastitis. Boswellic acid mediated AgNP (BANS) were oval, polydispersed (99.8 nm) with an minimum inhibitory concentration of 0.033 μg ml-1 against S. aureus, inhibitory concentration (IC50) of 30.04 μg ml-1 on mouse splenocytes and safe at an in vivo acute oral dose of 3.5 mg kg-1 in mice. Mastitis was induced in lactating mice by inoculating S. aureus (log10 5.60 cfu) and treated 6 h post-inoculation with BANS (0.12 mg kg-1, intramammary and intraperitoneal), and cefepime (1 mg kg-1, intraperitoneal). S. aureus inoculated mice showed increased bacterial load, neutrophil infiltration in mammary glands and elevated C-reactive protein (CRP) in serum. Oxidative stress was also observed with elevated malondialdehyde level, superoxide dismutase (SOD) and catalase (CAT) activities. BANS treatment significantly (P < 0.05) reduced bacterial load, CRP, SOD, CAT activities and neutrophil infiltration in affected mammary glands. BANS could be a potential therapeutic agent for managing bovine mastitis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
