التفاصيل البيبلوغرافية
| العنوان: |
Prädiktive Bedeutung der Reflexotalgie in der lokal radikalen Radiotherapie von Oropharynxkarzinomen. (German) |
| Alternate Title: |
[Predictive significance of reflex otalgia in local radical radiotherapy of oropharyngeal carcinomas]. (English) |
| المؤلفون: |
Beer, K T, von Briel, C, Lampret, T, Marré, S, Vetterli, D, Zbären, P, Greiner, R H |
| المصدر: |
Strahlentherapie und Onkologie; Jun1998, Vol. 174 Issue 6, p306-310, 5p |
| مصطلحات موضوعية: |
ABNORMAL reflexes, EARACHE, LONGITUDINAL method, METASTASIS, PARANEOPLASTIC syndromes, PROGNOSIS, RADIOTHERAPY, SQUAMOUS cell carcinoma, SURVIVAL analysis (Biometry), TUMOR classification, OROPHARYNGEAL cancer |
| مستخلص: |
Background: Patients with carcinomas of the upper aero-digestive tract often suffer from ear pain as a tumor associated syndrome. This prospective study examines the predictive and prognostic value of this symptom.Patients and Methods: Ninety-six consecutive patients who completed a locally radiotherapy of a carcinoma of the oropharynx were prospectively evaluated and followed. Forty-nine out of 96 patients stated the symptom, either spontaneously or after questioning. The 2 groups showed no difference regarding TNM-classification, histology and total dose. Overall survival, local control and disease specific survival were calculated according to Kaplan-Meier and compared by the log-rank test.Results: A clinically complete remission was obtained in significantly fewer patients with reflex-otalgia as compared to patients without reflex-otalgia, 61.2% versus 89.3%, p < 0.002. Local control of patients with reflex-otalgia was significantly less with 49%, mean follow-up 564 days, in comparison to local control in patients without reflex-otalgia, mean follow-up 613 days, p = 0.01. Disease specific survival was significantly worse for patients with reflex-otalgia, p < 0.012. The probability of local control of T1/T2 tumors with reflex-otalgia was similar to T3/T4 tumors without reflex-otalgia. Local control for all tumor categories combined is 74% for patients without reflex-otalgia versus 49% for patients with reflex-otalgia.Conclusion: In our patients, reflex-otalgia is a new and statistically significant parameter for the probability of local control and disease specific survival. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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