التفاصيل البيبلوغرافية
| العنوان: |
Assessment of the relationship between neutrophil lymphocyte ratio and prognostic factors in non-metastatic colorectal cancer. |
| المؤلفون: |
Borazan, Ersin, Balık, Ahmet Abdulhalik, Bozdağ, Zehra, Arık, Muhammed Kasım, Aytekin, Alper, Yılmaz, Latif, Elçi, Muhsin, Başkonuş, İlyas |
| المصدر: |
Turkish Journal of Surgery (Turkish Surgical Association); 2017, Vol. 33 Issue 3, p185-189, 5p, 3 Charts, 1 Graph |
| مصطلحات موضوعية: |
NEUTROPHILS, LYMPHOCYTES, PROGNOSIS, COLON cancer, REGRESSION analysis, SERUM albumin |
| مستخلص: |
Objective: Neutrophil-lymphocyte ratio still has a limited clinical use due to many non-cancer factors affecting neutrophils or lymphocytes in the present time. We aimed to evaluate the association between preoperative neutrophillymphocyte ratio and poor prognostic factors after curative elective colorectal surgery. Material and Methods: This clinical retrospective study was initiated with 95 patients, who had a curative surgical resection between 2003 and 2013. The patients were divided into two groups based on the preoperative neutrophillymphocyte ratio cut-off value above and below 3. The groups were compared for tumor localization, diameter, and staging; the histopathological perineural invasion; lymphovascular invasion; and overall survival. Univariate and multivariate Cox regression analyses were used to determine the role of neutrophil-lymphocyte ratio after stratification by several clinicopathological factors. Results: The mean age of patients was 59.79±1.48 (range, 23-90) years, and median follow-up period was 20.77±14.85 months. There was no significant difference in perineural or lymphovascular invasion, tumor size, stage, age, sex, and tumor location between the groups [Group 1 ratio >3 (n=52) and Group 2 ratio ≤3(n=43)]. Hemoglobin (p=0.035) and albumin levels (p=0.004) were lower in the Group 1. When the stage increased, differences between the rectal cancer groups were found. Overall survival was significantly lower in the Group 1 (p=0.013). Conclusions: The study showed that a high neutrophil-lymphocyte ratio had an adverse effect on overall survival in colorectal cancer patients who had a curative surgery. However, we could not establish any association between neutrophil-lymphocyte ratio and the factors such lymphovascular invasion, perineural invasion, tumor size expect hemoglobin and serum albumin levels. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
