التفاصيل البيبلوغرافية
| العنوان: |
Interest in initiating an early phase clinical trial: results of a longitudinal study of advanced cancer patients. |
| المؤلفون: |
Dunn, Laura B., Wiley, Jim, Garrett, Sarah, Hlubocky, Fay, Daugherty, Christopher, Trupin, Laura, Munster, Pamela, Dohan, Daniel |
| المصدر: |
Psycho-Oncology; Oct2017, Vol. 26 Issue 10, p1604-1610, 7p |
| مصطلحات موضوعية: |
CANCER patients, EARLY detection of cancer, MENTAL depression, GENERALIZED anxiety disorder, ANXIETY, TUMOR treatment, CLINICAL trials, DECISION making, LONGITUDINAL method, PATIENT satisfaction, PHYSICIAN-patient relations, QUALITY of life, QUESTIONNAIRES, TUMORS, PATIENT participation, PSYCHOLOGY |
| مستخلص: |
Objective: Enhanced recruitment of patients with advanced cancer (ACP) to early phase (EP) trials is needed. However, selective recruitment may affect the kinds of patients who are recruited. To address whether ACP who initiate EP trial enrollment differ from those who do not, we prospectively surveyed ACP well in advance of potential trial recruitment and followed them over time to identify those who initiated the recruitment process.Methods: EP trial initiation was defined as a patient being referred for screening to an active EP trial. Depression and anxiety were assessed with the Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder Scale (GAD-7), respectively. Demographic and disease characteristics, functional status, and patient preferences regarding decision making were examined as possible predictors of EP trial initiation.Results: Of the 78 advanced cancer patients in the cohort studied, 21 (27%) initiated EP trial participation, while 57 (73%) did not. Of those who initiated this process, 14 (67%) went on to enroll in an EP study. Level of depression severity was associated with EP trial initiation, with rates of initiation nearly three times higher (35% vs. 12%, p = 0.054) among patients with minimal to mild levels of depression compared to those with moderate or higher levels of depression. EP trial initiation was not associated with demographic or socioeconomic variables, cancer type, functional status, quality of life, or decision-making variables.Conclusions: The presence of elevated depressive symptoms may be associated with the EP trial recruitment and enrollment processes. This possible relationship warrants further study. Copyright © 2016 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] |
|
Copyright of Psycho-Oncology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder