التفاصيل البيبلوغرافية
| العنوان: |
Localization of parathyroid adenomas using C-methionine pet after prior inconclusive imaging. |
| المؤلفون: |
Noltes, Milou, Coester, Annemieke, Horst-Schrivers, Anouk, Dorgelo, Bart, Jansen, Liesbeth, Noordzij, Walter, Lemstra, Clara, Brouwers, Adrienne, Kruijff, Schelto |
| المصدر: |
Langenbeck's Archives of Surgery; Nov2017, Vol. 402 Issue 7, p1109-1117, 9p |
| مصطلحات موضوعية: |
PARATHYROID gland cancer, ADENOMA, METHIONINE, PARATHYROIDECTOMY, HYPERPARATHYROIDISM treatment |
| مستخلص: |
Purpose: Minimally invasive parathyroidectomy (MIP) is the recommended treatment in primary hyperparathyroidism (pHPT) for which accurate preoperative localization is essential. The current imaging standard consists of cervical ultrasonography (cUS) and MIBI-SPECT/CT. C-MET PET/CT has a higher resolution than MIBI-SPECT/CT. The aim of this study was to determine the diagnostic performance of C-MET PET/CT after initial inconclusive or negative localization. Methods: We performed a retrospective single center cohort study of patients with pHPT undergoing parathyroid surgery after prior negative imaging and later localization by means of C-MET PET/CT between 2006 and 2014. Preoperative localization by C-MET PET/CT was compared with later surgical localization, intraoperative quick PTH (IOPTH), duration of surgery, histopathology, and follow-up data. Also, differences in duration of surgery between the groups with and without correct preoperative localization were analyzed. Results: In 18/28 included patients a positive C-MET-PET/CT result corresponded to the surgical localized adenoma (64%). In 3/28 patients imaging was false positive and no adenoma was found. In 7/28 patients imaging was false negative at the side of the surgically identified adenoma. Sensitivity of C-MET PET/CT was 72% (18/25). Duration of surgery of correctly localized patients was significantly shorter compared to falsely negative localized patients ( p = 0.045). Conclusion: In an intention to treat C-MET-PET/CT correctly localized the parathyroid adenoma in 18/28 (64%) patients, after previous negative imaging. A preoperatively correct localized adenoma leads to a more focused surgical approach (MIP) potentially reducing duration of surgery and potentially healthcare costs. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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