التفاصيل البيبلوغرافية
| العنوان: |
Synthesis of 2-amino-4 H-chromen-4-ylphosphonates and β-phosphonomalonates via tandem Knoevenagel-Phospha-Michael reaction and antimicrobial evaluation of newly synthesized β-phosphonomalonates. |
| المؤلفون: |
Kour, Parteek, Kumar, Anil, Sharma, Rashmi, Chib, Reena, Ali Khan, Inshad, Rai, Vijai |
| المصدر: |
Research on Chemical Intermediates; Dec2017, Vol. 43 Issue 12, p7319-7329, 11p, 2 Diagrams, 5 Charts |
| مصطلحات موضوعية: |
TRIETHYLAMINE, INHIBITORY Concentration 50, ANTI-infective agents, QUINOLINE, FUNCTIONAL groups |
| مستخلص: |
In this manuscript we have demonstrated a new approach for the synthesis of 2-amino-4 H-chromen-4-ylphosphonates and β-phosphonomalonates linked 2-chloroquinoline-3-carbaldehyde by modified one-pot three-component tandem Knoevenagel-Phospha-Michael reaction of salicylaldehyde/aryl aldehyde/2-chloroquinoline-3-carbaldehyde, malononitrile/ethylcyanoacetate, and phosphite ester using triethylamine (1-10 mol%) in ethanol under reflux conditions. The desired products were obtained in 86-97% yield in 8-35 h. The advantages of this protocol are its operational simplicity, low catalytic loading, no side product formation, and high yield of product. The newly synthesized β-phosphonomalonates, diethyl-(2-chloroquinolin-3-yl)-2,2-dicyanoethyl)-phosphonates (4a- i) have been tested on two fungal strains ( C. albicans and A. fumigatus) and two bacterial strains ( S. aureus and E. coli) and their minimum inhibitory concentration was also determined by microbroth dilution method. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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