التفاصيل البيبلوغرافية
| العنوان: |
Effects of ginsenoside Rg1-loaded alginate-chitosan microspheres on human bone marrow stromal cells. |
| المؤلفون: |
Yu-Hai Guo, Shuai Zhao, Yan-Xin Du, Qing-Jia Xing, Bo-Lai Chen, Chu-Qin Yu |
| المصدر: |
Bioscience Reports; Jun2017, Vol. 37 Issue 3, p1-10, 10p, 1 Black and White Photograph, 1 Chart, 5 Graphs |
| مستخلص: |
The ginsenoside Rg1 is the most abundant compound in ginseng. Recent studies showed that Rg1 had neuroprotective effects on neuronal cells. The present study was to prepare Rg1-loaded alginate-chitosan microspheres and research the effects of microspheres on human bone marrow (BM) stromal cells (hBMSC). The alginate-chitosan microspheres were prepared by mechanical emulsification technique in combination with ion (Ca2+) and chitosan solidification. Subsequently, the microspheres were employed to load Rg1 ginseng extracts. The microspheres had a smooth surface and were spherical in shape. The average diameter of the microspheres was 3.95 μm. The loading efficiency was approximately 2.12%. The purity of isolated hBMSC was over 98.8%. Rg1-loaded microspheres could promote hBMSC proliferation and differentiation. Meanwhile, Rg1-loaded microspheres could also suppress hBMSC apoptosis induced by hypoxia-reoxygenation. In conclusion, these loaded microspheres may be used in the research of neuroprotective effects of Rg1. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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