التفاصيل البيبلوغرافية
| العنوان: |
Prognostic Significance Of Keratinization And Non Keratinization In Squamous Cell Cancer (Scc) Uterine Cervix. |
| المؤلفون: |
Singh, O. P., Yogi, Veenita, Ghori, H. U. |
| المصدر: |
Journal of Cancer Research & Therapeutics; 2017 Supplement, Vol. 13, pS35-S35, 1/4p |
| مصطلحات موضوعية: |
SQUAMOUS cell carcinoma, CERVIX uteri, KERATINIZATION, CERVICAL cancer |
| مستخلص: |
AIM- To determine the influence of keratinization on prognosis in squamous cell cancer (SCC) of uterine cervix. MATERIALS AND METHODS- A total of 105 patients with keratinized squamous cell carcinoma (KSCC) and non-keratinized squamous cell carcinoma (NKSCC) of cancer cervix that had started receiving treatment between 2012 and 2014 at dept. of radiotherapy GMC Bhopal were retrospectively studied and observed till date. Data were analyzed using Pearson Chisquare, Student's T tests. Kaplan-Meier and Cox Regression Proportional Hazards survival analysis was conducted in SPSS. RESULTS- The NKSCC group had 62 and the KSCC had 43 patients with mean age being 50 years in both groups, respectively. In general, patients with KSCC were more likely to have advanced stage (FIGO III and IV) disease while patients with NKSCC were more likely to have poorly differentiated neoplasm. The prevalence of lymph node metastasis remained similar in both histology types. Overall, the 5-year survival (among 44 patients who have completed 5 years of follow-up) in NKSCC was 63.64% (n= 14) as compared to 68.18% (n= 15) in the KSCC group (p= 0.75045). A total of 15 NKSCC and 16 KSCC patients did not received or completed treatment. 61 patients had completed 3 year follow-up at present among which 66% (n= 40) were having NKSCC and 44% (n= 21) KSCC while 3 year survival in NKSCC was 82.5% (n= 33) and in KSCC it was 57.14% (n= 12) (p= 0.032425). CONCLUSION- This is an institutional based study reporting the prognostic importance of keratinization in SCC. KSCC may be less radiosensitive and associated with shorter overall survival. Also, in SCC cervix, keratinization signifies striking reduction in survival of patients receiving complete treatment. [ABSTRACT FROM AUTHOR] |
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