التفاصيل البيبلوغرافية
| العنوان: |
microRNA-372 inhibits proliferation and induces apoptosis in human breast cancer cells by directly targeting E2F1. |
| المؤلفون: |
YA-XIN ZHAO, HUA-CHENG LIU, WEI-YANG YING, CHENG-YU WANG, YAO-JUN YU, WEI-JIAN SUN, JIE-FAN LIU |
| المصدر: |
Molecular Medicine Reports; Dec2017, Vol. 16 Issue 6, p8069-8075, 7p |
| مصطلحات موضوعية: |
MICRORNA genetics, GENETICS of breast cancer, CELL proliferation, NEOPLASTIC cell transformation, CANCER invasiveness, CANCER treatment |
| مستخلص: |
Breast cancer is the most prevalent cancer and the leading cause of cancer-associated mortalities among women worldwide today. Accumulating evidence suggested that miR-372 may serve important roles in the initiation and development of various human cancers. However, the role of miR-372 in breast cancer remains unknown. The present study demonstrated that the expression level of miR-372 in human breast cancer tissues and cell lines is significantly reduced compared with normal breast tissues cell lines. Furthermore, results of functional assays indicated that miR-372 inhibits cell proliferation and induces apoptosis in the MCF-7 human breast cancer cell line. E2F1 was identified as a direct functional target of miR-372 in breast cancer. In conclusion, the findings revealed that miR-372 may have the potential to act as a novel molecule for the diagnosis and therapy of patients with breast cancer. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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