التفاصيل البيبلوغرافية
| العنوان: |
An outbreak of skin infections in neonates due to a Staphylococcus aureus strain producing the exfoliative toxin A. |
| المؤلفون: |
Pimentel de Araujo, Fernanda, Tinelli, Marco, Battisti, Antonio, Ercoli, Angela, Anesi, Adriano, Pantosti, Annalisa, Monaco, Monica |
| المصدر: |
Infection; Feb2018, Vol. 46 Issue 1, p49-54, 6p, 1 Chart, 1 Graph |
| مصطلحات موضوعية: |
HOSPITALS, BACTERIAL toxins, BLISTERS, COMMUNICABLE diseases, CULTURES (Biology), DISEASE outbreaks, HYGIENE, POLYMERASE chain reaction, SANITATION, SKIN diseases, STAPHYLOCOCCUS aureus, METHICILLIN-resistant staphylococcus aureus, MICROARRAY technology, SEQUENCE analysis |
| مصطلحات جغرافية: |
ITALY |
| مستخلص: |
Purpose: Staphylococcus aureus is an important cause of infections in hospitalized neonates. Preterm or low birthweight infants are especially at risk to develop a S. aureus infection due to the immaturity of the immune system, length of hospital stay and invasive procedures. Exfoliative toxin (ET)-producing S. aureus is often responsible for neonatal infections, causing clinical manifestations such as staphylococcal scalded skin syndrome, characterized by both localized blisters or generalized exfoliation of the skin.Methods: We describe an outbreak due to an S. aureus strain producing ETA occurring in a local hospital in Northern Italy. Molecular typing of the isolates included spa typing and multilocus sequence typing. DNA microarray hybridization was also performed on one representative strain.Results: In the period from July 2013 to February 2014, 12 neonates presented with skin infections, mainly bullae or pustules. Cultures of skin swabs yielded methicillin-susceptible S. aureus (MSSA). By molecular typing, an epidemic strain (t1393/ST5) was identified in nine neonates; microarray analysis and PCR revealed that it contained the ETA encoding gene. Screening of staff, mothers and healthy neonates and environmental cultures did not reveal the presence of the epidemic strain. However, the father of an infected neonate was found to be a carrier of MSSA t1393 five months after the outbreak started.Conclusion: Implementation of hygiene procedures and sanitization of the ward twice terminated the outbreak. Timely surveillance of infections, supported by molecular typing, is fundamental to prevent similar episodes among neonates. [ABSTRACT FROM AUTHOR] |
|
Copyright of Infection is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Find this article in full text from Springer Verlag. 
Full Text Finder