التفاصيل البيبلوغرافية
| العنوان: |
mRNA Expression of Interferon Regulatory Factors during Acute Rejection of Liver Transplants in Patients with Autoimmune Hepatitis. |
| المؤلفون: |
Nasiri, M., Geramizadeh, B., Nabavizadeh, S. H., Male-Hosseini, S. A., Karimis, M. H., Saadat, I. |
| المصدر: |
International Journal of Organ Transplantation Medicine; Jan2018, Vol. 9 Issue 1, p34-40, 7p |
| مصطلحات موضوعية: |
CHRONIC active hepatitis, LIVER transplantation, INTERFERON regulatory factors, IMMUNE response, GRAFT rejection, THERAPEUTICS |
| مستخلص: |
Background: Interferon regulatory factors (IRFs) can play a critical role in the regulation of many facets of innate and adaptive immune responses through transcriptional activation of type I interferons, other proinflammatory cytokines, and chemokines. However, their roles in transplantation immunity still remain to be elucidated. Objective: To evaluate the time course of mRNA expression of all 9 members of IRFs family of transcription factors during liver allograft acute rejection. Methods: Blood samples of 19 patients with autoimmune hepatitis receiving liver transplants were collected on days 1, 3, 5, and 7 post-transplantation. The patients were followed for 6 months after transplantation and divided into two groups of acute rejection (AR) (n=4) and non-acute rejection (non-AR) (n=15). Results: All of the studied transcription factors were down-regulated in AR-group on days 3, 5, and 7 post-transplantation compared to non-AR group. The mean±SEM IRF5 on day 7 post-transplantation was significantly (p=0.005) lower in AR-group than in non-AR group (0.7±0.21 vs. 1.91±0.27, respectively); expression of other IRFs family members was not significantly different between the two groups on days 3, 5, and 7 post-transplantation. Conclusion: IRF5 may have an important role during the acute rejection of liver transplants. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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