التفاصيل البيبلوغرافية
| العنوان: |
Beneficial Effects of n-3 Fatty Acids on Cardiometabolic and Inflammatory Markers in Type 2 Diabetes Mellitus: A Clinical Trial. |
| المؤلفون: |
Mazaherioun, Maryam, Djalali, Mahmoud, Koohdani, Fariba, Javanbakht, Mohammad Hassan, Zarei, Mahnaz, Beigy, Maani, Ansari, Samaneh, Rezvan, Neda, Saedisomeolia, Ahmad |
| المصدر: |
Medical Principles & Practice; Feb2018, Vol. 26 Issue 6, p535-541, 7p |
| مصطلحات موضوعية: |
UNSATURATED fatty acids, MONOCYTE chemotactic factor, PEOPLE with diabetes, TYPE 2 diabetes treatment, PLACEBOS |
| مستخلص: |
Objective: To determine the effect of supplementation with n-3 polyunsaturated fatty acids (PUFAs) on circulatory resistin and monocyte chemoattractant protein 1 (MCP-1) levels in type 2 diabetes mellitus (T2DM) patients.Subjects and Methods: This was a 10-week, placebo-controlled, double-blind, randomized trial of n-3 PUFAs (2,700 mg/day) versus placebo (soft gels containing 900 mg of edible paraffin). Forty-four T2DM patients were supplemented with n-3 PUFAs and another 44 patients received placebo (3 patients discontinued the trial). Serum resistin, MCP-1, and the lipid profile were measured before and after supplementation. The adiponectin-resistin index (1 + log10 [resistin] - log10 [adiponectin]) and atherogenic index (log10 triglyceride/high-density lipoprotein cholesterol) of plasma (an indicator of cardiovascular complications) were assessed. The independent Student t test was used to assess the differences between the supplement and placebo groups and the paired t test to analyze the before/after changes.Results: In this study, n-3 PUFAs reduced serum MCP-1 levels (from 260.5 to 230.5 pg/mL; p = 0.002), but they remained unchanged in the placebo group. n-3 PUFAs could not decrease serum resistin levels. The adiponectin-resistin index was significantly reduced after supplementation with n-3 PUFAs when compared to the placebo. The atherogenic index was also significantly improved after supplementation with n-3 PUFAs (from 1.459 to 1.412; p = 0.006).Conclusions: The MCP-1 levels and lipid profile were improved after supplementation with n-3 PUFAs, but resistin serum levels were not changed. Hence, the anti-inflammatory effects of n-3 PUFAs might be mediated by targeting MCP-1. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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